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Table 2

Selection of EphA2 peptides for analysis

A. Selected HLA-A2 presented EphA2 peptides
Sequence start amino acid #AA sequence of nonamerBinding scoreaPeptide generated by proteasomePeptide synthesized for analysis
883 TLADFDPRV 1084 Yes Yes 
546 VLLLVLAGV 1006 Yes Yes 
550 VLAGVGFFI 556 No No 
58 IMNDMPIYM 138 No No 
961 SLLGLKDQV 127 Yes Yes 
253 WLVPIGQCL 98 No No 
12 LLWGCALAA 71 No No 
391 GLTRTSVTV 70 Yes Yes 
120 NLYYAESDL 68 No No 
162 KLNVEERSV 49 Yes Yes 
A. Selected HLA-A2 presented EphA2 peptides
Sequence start amino acid #AA sequence of nonamerBinding scoreaPeptide generated by proteasomePeptide synthesized for analysis
883 TLADFDPRV 1084 Yes Yes 
546 VLLLVLAGV 1006 Yes Yes 
550 VLAGVGFFI 556 No No 
58 IMNDMPIYM 138 No No 
961 SLLGLKDQV 127 Yes Yes 
253 WLVPIGQCL 98 No No 
12 LLWGCALAA 71 No No 
391 GLTRTSVTV 70 Yes Yes 
120 NLYYAESDL 68 No No 
162 KLNVEERSV 49 Yes Yes 
B. Selected HLA-DR4 presented EphA2 peptides
Sequence start core AA#AA sequence of nonamer coreBinding scoreaPeptide synthesized for in vitro analysis
666 IMGQFSHHN 577 663EAGIMGQFSHHNIIR677 
67 YSVCNVMSG 95 63PIYMYSVCNVMSG75 
55 MQNIMNDMP 39 53DLMQNIMNDMPIYMYS68 
B. Selected HLA-DR4 presented EphA2 peptides
Sequence start core AA#AA sequence of nonamer coreBinding scoreaPeptide synthesized for in vitro analysis
666 IMGQFSHHN 577 663EAGIMGQFSHHNIIR677 
67 YSVCNVMSG 95 63PIYMYSVCNVMSG75 
55 MQNIMNDMP 39 53DLMQNIMNDMPIYMYS68 
a

The higher the binding score, the greater the stability of the predicted peptide-MHC complex. Binding scores and qualitative determination of proteasomal processing were predicted using on-line algorithms as described in “Materials and Methods.”

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