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Table 3

Effect of AFB1 exposure on various strains of mice

StrainPhenotypeExposureNo. of pups injectedNo. of pups weanedPercentage surviving to weaningAnimals with HCCPercentage having HCC
C57BL6/J HCC resistant AFB1 16 15 94% 4 27% 
C57BL6/J HCC resistant Tricaprylin 7 7 100% 0 0% 
DBA/2J HCC susceptible AFB1 21 10 47% 9 90% 
DBA/2J HCC susceptible Tricaprylin 6 6 100% 0 0% 
B6.129S2-Trp53tm1Tyj p53 (−/−) AFB1 6 5 83% 0a 0%a 
B6.129S2-Trp53tm1Tyj p53 (+/−) AFB1 10 10 100% 1 10% 
C57BL/6J-TgN(Alb1HBV)44Bri HBV(+) AFB1 7 7 100% 7 100% 
C57BL/6J-TgN(Alb1HBV)44Bri B6/129S2-Trp53tm1Tyj HBV(+)/p53 (+/−) AFB1 3 3 100% 3 100% 
StrainPhenotypeExposureNo. of pups injectedNo. of pups weanedPercentage surviving to weaningAnimals with HCCPercentage having HCC
C57BL6/J HCC resistant AFB1 16 15 94% 4 27% 
C57BL6/J HCC resistant Tricaprylin 7 7 100% 0 0% 
DBA/2J HCC susceptible AFB1 21 10 47% 9 90% 
DBA/2J HCC susceptible Tricaprylin 6 6 100% 0 0% 
B6.129S2-Trp53tm1Tyj p53 (−/−) AFB1 6 5 83% 0a 0%a 
B6.129S2-Trp53tm1Tyj p53 (+/−) AFB1 10 10 100% 1 10% 
C57BL/6J-TgN(Alb1HBV)44Bri HBV(+) AFB1 7 7 100% 7 100% 
C57BL/6J-TgN(Alb1HBV)44Bri B6/129S2-Trp53tm1Tyj HBV(+)/p53 (+/−) AFB1 3 3 100% 3 100% 
a

All animals died of lymphoma.

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