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Table 2

Statistical significance of human susceptibility loci after collapsing genotypes

Locus (mouse)Locus (human)All (231 cases, 256 controls)Males (187 cases, 189 controls)
χ2POR95% CIχ2POR95% CI
Ephx1 EPHX1-exon3(1)a 2.30 0.13 1.57 0.87–2.83 0.42 0.51 1.24 0.6–2.41 
Ephx1 EPHX1-exon4 0.21 0.64 1.13 0.68–1.86 0.03 0.85 1.05 0.59–1.85 
Ephx2 EPHX2 9.1 0.002 2.06 1.28–3.32 10.6 0.001 2.49 1.42–4.36 
Gsta4 GSTA4 0.95 0.33 0.84 0.58–1.20 4.52 0.03 1.55 1.03–2.35 
Gstm1 GSTM1 0.95 0.33 0.83 0.57–1.21 0.83 0.36 0.82 0.54–1.25 
Gstt1 GSTT1 0.38 0.53 0.88 0.59–1.31 0.02 0.88 0.96 0.62–1.50 
Locus (mouse)Locus (human)All (231 cases, 256 controls)Males (187 cases, 189 controls)
χ2POR95% CIχ2POR95% CI
Ephx1 EPHX1-exon3(1)a 2.30 0.13 1.57 0.87–2.83 0.42 0.51 1.24 0.6–2.41 
Ephx1 EPHX1-exon4 0.21 0.64 1.13 0.68–1.86 0.03 0.85 1.05 0.59–1.85 
Ephx2 EPHX2 9.1 0.002 2.06 1.28–3.32 10.6 0.001 2.49 1.42–4.36 
Gsta4 GSTA4 0.95 0.33 0.84 0.58–1.20 4.52 0.03 1.55 1.03–2.35 
Gstm1 GSTM1 0.95 0.33 0.83 0.57–1.21 0.83 0.36 0.82 0.54–1.25 
Gstt1 GSTT1 0.38 0.53 0.88 0.59–1.31 0.02 0.88 0.96 0.62–1.50 
a

Contrasting individuals with CC genotypes versus individuals with CT and TT genotypes.

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