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Table 2

Synergistic effects of IFNα and cotylenin A on the growth of human lung carcinoma cell linesa

Cell linebIC50 for cotylenin A (μg/ml)Ratio (−/+)
− IFNα+ IFNα
Adenocarcinoma    
 A549 15.4 ± 1.1 1.8 ± 0.1 8.6 
 PC7 37.6 ± 3.1 3.6 ± 0.3 10.4 
 PC9 34.8 ± 2.9 7.9 ± 0.5 4.4 
 PC14 28.6 ± 2.2 2.1 ± 3.2 13.6 
 ABC-1 16.5 ± 1.8 2.2 ± 0.2 7.5 
Squamous cell carcinoma    
 EBC-1 6.3 ± 4.2 0.8 ± 0.1 7.9 
 LK2 26.8 ± 2.4 6.1 ± 0.8 4.4 
Large cell carcinoma    
 Lu65 16.3 ± 1.4 3.1 ± 0.3 5.3 
 Lu99 7.5 ± 0.7 0.8 ± 0.1 9.4 
Small cell carcinoma    
 Lu135 4.8 ± 0.4 1.5 ± 0.1 3.2 
 H69 14.8 ± 1.2 3.4 ± 0.2 4.4 
Cell linebIC50 for cotylenin A (μg/ml)Ratio (−/+)
− IFNα+ IFNα
Adenocarcinoma    
 A549 15.4 ± 1.1 1.8 ± 0.1 8.6 
 PC7 37.6 ± 3.1 3.6 ± 0.3 10.4 
 PC9 34.8 ± 2.9 7.9 ± 0.5 4.4 
 PC14 28.6 ± 2.2 2.1 ± 3.2 13.6 
 ABC-1 16.5 ± 1.8 2.2 ± 0.2 7.5 
Squamous cell carcinoma    
 EBC-1 6.3 ± 4.2 0.8 ± 0.1 7.9 
 LK2 26.8 ± 2.4 6.1 ± 0.8 4.4 
Large cell carcinoma    
 Lu65 16.3 ± 1.4 3.1 ± 0.3 5.3 
 Lu99 7.5 ± 0.7 0.8 ± 0.1 9.4 
Small cell carcinoma    
 Lu135 4.8 ± 0.4 1.5 ± 0.1 3.2 
 H69 14.8 ± 1.2 3.4 ± 0.2 4.4 
a

Cells were cultured with various concentrations of cotylenin A in the presence or absence of 600 IU/ml IFNα for 6 days. IC50 of Lu65 cells for IFNα alone was 3402 ± 194 IU/ml, and the IC50s of the other cells were >6000 IU/ml. The values are the mean ± SD of four determinations.

b

p53 status is wild type in A549 and Lu99 cell lines and mutated in the other cell lines.

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