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Table 1

Potentiation of the growth-inhibitory activities of various agents in human lung carcinoma A549 cells by IFNαa

CompoundGrowth inhibition (IC50)Ratio (−/+)
− IFNα+ IFNα
5-Fluorouracil (μg/ml) 0.81 ± 0.06 0.59 ± 0.04 1.4 
Hydroxyurea (μm407 ± 38 149 ± 11 2.7 
Doxorubicin (ng/ml) 31.4 ± 2.8 22.8 ± 1.9 1.4 
Cis-platin (ng/ml) 312 ± 3.0 259 ± 22 1.2 
Etoposide (μg/ml) 5.13 ± 0.4 3.03 ± 0.2 1.7 
Camptotecin (ng/ml) 124 ± 8.1 72.2 ± 4.8 1.7 
Actinomycin D (ng/ml) 0.31 ± 0.02 0.24 ± 0.02 1.3 
All-trans retinoic acid (μm>36 >36  
13-Cis retinoic acid (μm>36 >36  
1α,25-Dihydroxyvitamin D3 (ng/ml) >90 >90  
Cotylenin A (μg/ml) 15.4 ± 1.1 1.8 ± 0.1 8.6 
Sodium butyrate (μm521 ± 43 164 ± 11 3.2 
Dimethyl sulfoxide (mm257 ± 21 78.2 ± 7.3 3.3 
Hexamethylene bisacetamide (mm12.7 ± 1.1 4.4 ± 0.4 2.9 
Isopentenyladenine (μg/ml) 86.1 ± 8.2 69.3 ± 5.9 1.3 
8-Cl-cAMP (μm24.7 ± 1.9 18.8 ± 1.6 1.3 
Bufalin (nm1.6 ± 0.1 1.8 ± 0.1 0.9 
Trichostatin A (ng/ml) 71.5 ± 7.6 48.2 ± 4.1 1.5 
Genistein (μg/ml) 8.2 ± 0.7 6.3 ± 0.6 1.3 
Wortmannin (μm4.9 ± 0.5 3.2 ± 0.3 1.5 
CompoundGrowth inhibition (IC50)Ratio (−/+)
− IFNα+ IFNα
5-Fluorouracil (μg/ml) 0.81 ± 0.06 0.59 ± 0.04 1.4 
Hydroxyurea (μm407 ± 38 149 ± 11 2.7 
Doxorubicin (ng/ml) 31.4 ± 2.8 22.8 ± 1.9 1.4 
Cis-platin (ng/ml) 312 ± 3.0 259 ± 22 1.2 
Etoposide (μg/ml) 5.13 ± 0.4 3.03 ± 0.2 1.7 
Camptotecin (ng/ml) 124 ± 8.1 72.2 ± 4.8 1.7 
Actinomycin D (ng/ml) 0.31 ± 0.02 0.24 ± 0.02 1.3 
All-trans retinoic acid (μm>36 >36  
13-Cis retinoic acid (μm>36 >36  
1α,25-Dihydroxyvitamin D3 (ng/ml) >90 >90  
Cotylenin A (μg/ml) 15.4 ± 1.1 1.8 ± 0.1 8.6 
Sodium butyrate (μm521 ± 43 164 ± 11 3.2 
Dimethyl sulfoxide (mm257 ± 21 78.2 ± 7.3 3.3 
Hexamethylene bisacetamide (mm12.7 ± 1.1 4.4 ± 0.4 2.9 
Isopentenyladenine (μg/ml) 86.1 ± 8.2 69.3 ± 5.9 1.3 
8-Cl-cAMP (μm24.7 ± 1.9 18.8 ± 1.6 1.3 
Bufalin (nm1.6 ± 0.1 1.8 ± 0.1 0.9 
Trichostatin A (ng/ml) 71.5 ± 7.6 48.2 ± 4.1 1.5 
Genistein (μg/ml) 8.2 ± 0.7 6.3 ± 0.6 1.3 
Wortmannin (μm4.9 ± 0.5 3.2 ± 0.3 1.5 
a

Cells were incubated with various concentrations of the test compounds in the presence or absence of 600 IU/ml IFNα for 6 days. Ratio (−/+), IC50 without IFNα:IC50 with IFNα. The values are the mean ± SD of four determinations.

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