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Table 3

Thymoma cases with shared genetic imbalances at few loci despite divergent morphology

Shared LOHsaDifferent WHO types, modified Masaoka’s stage (no. case numbers)
5q15-31 (APCAB stage II (no. 56*)b,c; B2 stage II (no. 30), IVB (no. 32), B3 stage III (no. 44), IVA (no. 45), III (no. 46) 
6p21.3 (MHCA stage II (no. 1); B3 stage II (no. 42) 
6p21.3 and 6q25.2-25.3 AB stage II (no. 16), I (no. 26); C stage IVB (no. 55) 
6p21.3, 6q14-15 and 6q25.2-25.3 A stage I (no. 5); B3 stage II (no. 37) 
6q21 A stage Id (no. 3), AB stage I (no. 13); B3 stage II (no. 43), IVB (no. 50) 
7p15.3 and 8p11.21 AB stage I (no. 19); B3 stage III (no. 41), B3 stage IVA (no. 48) 
16q22.1 (CDH1A stage I (no. 11); B3 stage IVA (no. 51), C stage IVB (no. 54) 
17p13.1 (p53A stage I (no. 11); B2 stage IVA (no. 29) 
Shared LOHsaDifferent WHO types, modified Masaoka’s stage (no. case numbers)
5q15-31 (APCAB stage II (no. 56*)b,c; B2 stage II (no. 30), IVB (no. 32), B3 stage III (no. 44), IVA (no. 45), III (no. 46) 
6p21.3 (MHCA stage II (no. 1); B3 stage II (no. 42) 
6p21.3 and 6q25.2-25.3 AB stage II (no. 16), I (no. 26); C stage IVB (no. 55) 
6p21.3, 6q14-15 and 6q25.2-25.3 A stage I (no. 5); B3 stage II (no. 37) 
6q21 A stage Id (no. 3), AB stage I (no. 13); B3 stage II (no. 43), IVB (no. 50) 
7p15.3 and 8p11.21 AB stage I (no. 19); B3 stage III (no. 41), B3 stage IVA (no. 48) 
16q22.1 (CDH1A stage I (no. 11); B3 stage IVA (no. 51), C stage IVB (no. 54) 
17p13.1 (p53A stage I (no. 11); B2 stage IVA (no. 29) 
a

LOHs were detected by microsatellite analysis.

b

Capital letters A, AB, B2, B3, C represent WHO thymoma types.

c

In AB case no. 56

*

, only CGH was applied, because only tumor material but no nonneoplastic tissue was available. Numbers in parenthesis represent the individual case numbers as applied in Figs. 2 and 3.

d

The pairs with the most discrepant clinicopathological features are highlighted by bold letters.

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