Thymoma cases with shared genetic imbalances at few loci despite divergent morphology
| Shared LOHsa . | Different WHO types, modified Masaoka’s stage (no. case numbers) . |
|---|---|
| 5q15-31 (APC) | AB stage II (no. 56*)b,c; B2 stage II (no. 30), IVB (no. 32), B3 stage III (no. 44), IVA (no. 45), III (no. 46) |
| 6p21.3 (MHC) | A stage II (no. 1); B3 stage II (no. 42) |
| 6p21.3 and 6q25.2-25.3 | AB stage II (no. 16), I (no. 26); C stage IVB (no. 55) |
| 6p21.3, 6q14-15 and 6q25.2-25.3 | A stage I (no. 5); B3 stage II (no. 37) |
| 6q21 | A stage Id (no. 3), AB stage I (no. 13); B3 stage II (no. 43), IVB (no. 50) |
| 7p15.3 and 8p11.21 | AB stage I (no. 19); B3 stage III (no. 41), B3 stage IVA (no. 48) |
| 16q22.1 (CDH1) | A stage I (no. 11); B3 stage IVA (no. 51), C stage IVB (no. 54) |
| 17p13.1 (p53) | A stage I (no. 11); B2 stage IVA (no. 29) |
| Shared LOHsa . | Different WHO types, modified Masaoka’s stage (no. case numbers) . |
|---|---|
| 5q15-31 (APC) | AB stage II (no. 56*)b,c; B2 stage II (no. 30), IVB (no. 32), B3 stage III (no. 44), IVA (no. 45), III (no. 46) |
| 6p21.3 (MHC) | A stage II (no. 1); B3 stage II (no. 42) |
| 6p21.3 and 6q25.2-25.3 | AB stage II (no. 16), I (no. 26); C stage IVB (no. 55) |
| 6p21.3, 6q14-15 and 6q25.2-25.3 | A stage I (no. 5); B3 stage II (no. 37) |
| 6q21 | A stage Id (no. 3), AB stage I (no. 13); B3 stage II (no. 43), IVB (no. 50) |
| 7p15.3 and 8p11.21 | AB stage I (no. 19); B3 stage III (no. 41), B3 stage IVA (no. 48) |
| 16q22.1 (CDH1) | A stage I (no. 11); B3 stage IVA (no. 51), C stage IVB (no. 54) |
| 17p13.1 (p53) | A stage I (no. 11); B2 stage IVA (no. 29) |
LOHs were detected by microsatellite analysis.
Capital letters A, AB, B2, B3, C represent WHO thymoma types.
In AB case no. 56
, only CGH was applied, because only tumor material but no nonneoplastic tissue was available. Numbers in parenthesis represent the individual case numbers as applied in Figs. 2 and 3.
The pairs with the most discrepant clinicopathological features are highlighted by bold letters.