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Table 2

Loci showing frequent allelic imbalances in advanced thymoma

LocusGeneStageaP              b
IIIIIIversusIV
8p11.21 (Unknown) 1/10 2/21 2/10  4/8 0.0284 
16q22.1 CDH1 0/11 3/20 2/11  4/9 0.0402 
LocusGeneStageaP              b
IIIIIIversusIV
8p11.21 (Unknown) 1/10 2/21 2/10  4/8 0.0284 
16q22.1 CDH1 0/11 3/20 2/11  4/9 0.0402 
a

Stage: Masaoka’s staging system (29) as modified by Shimosato and Mukai (2).

b

P: stage I–III versus IV, calculated using Fisher’s exact test. Allelic imbalances at 8p11.21, and 16q22.1 were significantly more frequent in stage IV metastatic cases than those in stage I–III thymomas.

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