American Association for Cancer Research

Table 2

Loci showing frequent allelic imbalances in advanced thymoma

Locus	Gene	Stage^a							P ^b
Locus	Gene			I	II	III	versus	IV	P ^b
8p11.21	(Unknown)	1/10	2/21	2/10		4/8	0.0284
16q22.1	CDH1	0/11	3/20	2/11		4/9	0.0402

Locus	Gene	Stage^a							P ^b
Locus	Gene			I	II	III	versus	IV	P ^b
8p11.21	(Unknown)	1/10	2/21	2/10		4/8	0.0284
16q22.1	CDH1	0/11	3/20	2/11		4/9	0.0402

Stage: Masaoka’s staging system (29) as modified by Shimosato and Mukai (2).

P: stage I–III versus IV, calculated using Fisher’s exact test. Allelic imbalances at 8p11.21, and 16q22.1 were significantly more frequent in stage IV metastatic cases than those in stage I–III thymomas.

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