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Table 1

Loci showing recurrent allelic imbalances according to WHO classification of thymic tumors

LocusGeneWHO thymoma typea
AABB2B3C
3p14.2 FHIT    (16%)  
5q21-22 APC   33%b (16%)*  
6p21.3 MHC 27% 25%  41% 75% 
6q14-15  27%   37% 75% 
6q21     33%  
6q25.2-25.3  36% 37% 33% 39% 100% 
7p15.3    50%   
8p11.21    33% 30%  
13q14.3 RB  27%  28%*  
16q22.1 CDH1   50%  50% 
16q23-24.1      50% 
17p13.1 p53    (16%)*  
LocusGeneWHO thymoma typea
AABB2B3C
3p14.2 FHIT    (16%)  
5q21-22 APC   33%b (16%)*  
6p21.3 MHC 27% 25%  41% 75% 
6q14-15  27%   37% 75% 
6q21     33%  
6q25.2-25.3  36% 37% 33% 39% 100% 
7p15.3    50%   
8p11.21    33% 30%  
13q14.3 RB  27%  28%*  
16q22.1 CDH1   50%  50% 
16q23-24.1      50% 
17p13.1 p53    (16%)*  
a

Type: histological type according to the WHO classification of thymic tumors (4).

b

Percentage (%): loci showing recurrent LOHs or amplification in at least 25% of informative cases in each thymoma type.

*

Combined LOHs in three advanced B3 thymomas (stage III-IVA): case nos. 44, 45, 46. In addition, case nos. 44 and 46 shared the LOH at 3p14.2 (FHIT; Fig. 3). Percentages of LOHs in this subset of B3 thymomas are given in brackets when <25%.

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