Genes that induce senescence-like growth arrest in tumor cells
| Gene . | Tumor cell line . | Reference . |
|---|---|---|
| p53 | EJ bladder caa; NSCLC H358 lung ca | (30, 104) |
| p63 | EJ bladder ca | (105) |
| p73 | EJ bladder ca | (105) |
| RB | MDA-MB-468 breast ca; 5637 bladder ca; Saos-2 osteosarcoma | (106) |
| p21 Waf1/Cip1/Sdi1 | HT1080 fibrosarcoma; EJ bladder carcinoma; H1299 lung ca | (31, 32, 107, 108) |
| p16 Ink4A | U-1242 MG glioma; U251 glioma; U2-OS osteosarcoma | (33, 109, 110) |
| P57 Kip2 | U343 MG-A, U87 MG, and U373 MG astrocytoma | (111) |
| p15 Ink4B | U251 glioma | (110) |
| E2 papillomavirus protein (inhibitor of E6 and E7) | HeLa, HT-3, and CaSki cervical ca | (37)(38) |
| IGFBP-rP1 | M12 prostate ca; MCF-7 breast ca | (100, 112) |
| Activated RAF-1 | LNCaP prostate ca | (75) |
| Activated MKK6 | U2-OS osteosarcoma | (43) |
| Gene . | Tumor cell line . | Reference . |
|---|---|---|
| p53 | EJ bladder caa; NSCLC H358 lung ca | (30, 104) |
| p63 | EJ bladder ca | (105) |
| p73 | EJ bladder ca | (105) |
| RB | MDA-MB-468 breast ca; 5637 bladder ca; Saos-2 osteosarcoma | (106) |
| p21 Waf1/Cip1/Sdi1 | HT1080 fibrosarcoma; EJ bladder carcinoma; H1299 lung ca | (31, 32, 107, 108) |
| p16 Ink4A | U-1242 MG glioma; U251 glioma; U2-OS osteosarcoma | (33, 109, 110) |
| P57 Kip2 | U343 MG-A, U87 MG, and U373 MG astrocytoma | (111) |
| p15 Ink4B | U251 glioma | (110) |
| E2 papillomavirus protein (inhibitor of E6 and E7) | HeLa, HT-3, and CaSki cervical ca | (37)(38) |
| IGFBP-rP1 | M12 prostate ca; MCF-7 breast ca | (100, 112) |
| Activated RAF-1 | LNCaP prostate ca | (75) |
| Activated MKK6 | U2-OS osteosarcoma | (43) |
ca, carcinoma; NSCLC, non-small cell lung cancer.