Skip to Main Content
Table 1

Genes that induce senescence-like growth arrest in tumor cells

GeneTumor cell lineReference
p53 EJ bladder caa; NSCLC H358 lung ca (30, 104) 
p63 EJ bladder ca  (105)  
p73 EJ bladder ca  (105)  
RB MDA-MB-468 breast ca; 5637 bladder ca; Saos-2 osteosarcoma  (106)  
p21              Waf1/Cip1/Sdi1 HT1080 fibrosarcoma; EJ bladder carcinoma; H1299 lung ca (31, 32, 107, 108) 
p16              Ink4A U-1242 MG glioma; U251 glioma; U2-OS osteosarcoma (33, 109, 110) 
P57              Kip2 U343 MG-A, U87 MG, and U373 MG astrocytoma  (111)  
p15              Ink4B U251 glioma  (110)  
E2 papillomavirus protein (inhibitor of E6 and E7) HeLa, HT-3, and CaSki cervical ca (37)(38) 
IGFBP-rP1 M12 prostate ca; MCF-7 breast ca (100, 112) 
Activated RAF-1 LNCaP prostate ca  (75)  
Activated MKK6 U2-OS osteosarcoma  (43)  
GeneTumor cell lineReference
p53 EJ bladder caa; NSCLC H358 lung ca (30, 104) 
p63 EJ bladder ca  (105)  
p73 EJ bladder ca  (105)  
RB MDA-MB-468 breast ca; 5637 bladder ca; Saos-2 osteosarcoma  (106)  
p21              Waf1/Cip1/Sdi1 HT1080 fibrosarcoma; EJ bladder carcinoma; H1299 lung ca (31, 32, 107, 108) 
p16              Ink4A U-1242 MG glioma; U251 glioma; U2-OS osteosarcoma (33, 109, 110) 
P57              Kip2 U343 MG-A, U87 MG, and U373 MG astrocytoma  (111)  
p15              Ink4B U251 glioma  (110)  
E2 papillomavirus protein (inhibitor of E6 and E7) HeLa, HT-3, and CaSki cervical ca (37)(38) 
IGFBP-rP1 M12 prostate ca; MCF-7 breast ca (100, 112) 
Activated RAF-1 LNCaP prostate ca  (75)  
Activated MKK6 U2-OS osteosarcoma  (43)  
a

ca, carcinoma; NSCLC, non-small cell lung cancer.

Close Modal

or Create an Account

Close Modal
Close Modal