Analysis of EXO1 variants in CRC probands and controls
Results of the Finnish, Dutch/Norwegian, United Kingdom, Danish, and combined data sets. The last column lists the 9 candidate EXO1 mutations reported previously (13).
| Exon . | Nucleotide change . | Protein change . | Finnish CRC probands . | Finnish controls . | Dutch/Norwegian CRC probands . | Dutch controls . | United Kingdom CRC probands . | United Kingdom controls . | Danish CRC probands . | Danish controls . | Combined CRC probands . | Combined controls . | Wu et al. (13) CRC probands . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | T to C | Val27Ala | –/109 | –/112 | –/155 | –/92 | –/264 | –/204 | 1/258 | ||||
| 4 | G to A | Glu109Lys | –/18 | –/20 | –/155 | –/92 | –/173 | –/112 | 2/258 | ||||
| 5 | G to T | Ala137Ser | –/18 | –/20 | 1/142 | –/71 | 1/160 | –/91 | |||||
| 9 | T to G | Leu410Arg | –/109 | –/112 | 1/154 | –/114 | 1/263 | –/226 | 2/258 | ||||
| 10 | T to G | Phe438Cys | –/18 | –/20 | 1/154 | –/104 | 1/172 | –/124 | |||||
| 11 | A to G | Ser610Gly | 1/300 | –/373 | 1/155 | –/52 | 2/418 | 1/208 | 1/97 | –/95 | 5/970 | 1/728 | 3/258 |
| 11 | C to T | Pro640Ser | 3/300 | 3/373 | 3/150 | –/52 | 5/418 | 2/208 | 1/97 | 2/95 | 12/965 | 7/728 | 1/258 |
| 11 | C to G | Pro640Ala | 1/300 | 1/373 | 1/150 | 1/52 | 3/418 | 2/208 | 2/97 | –/95 | 7/965 | 4/730 | 1/258 |
| 11 | C to T | Asp661Asp | –/18 | –/20 | 2/150 | –/52 | 2/168 | –/72 | |||||
| 13 | IVS12-1 | G to C | –/83 | –/504 | 1/149 | 3/200 | 1/232 | 3/704 | 1/258 | ||||
| 13 | IVS12-1 | G to A | –/83 | 1/504 | –/149 | –/200 | –/232 | 1/704 | |||||
| 13 | G to A | Gly759Glu | 3/109 | 11/112 | 1/149 | 1/200 | 4/258 | 12/312 | 2/258 | ||||
| 13 | C to T | Pro770Leu | –/109 | –/112 | –/149 | –/200 | –/258 | –/312 | 1/258 | ||||
| 14 | C to T | Ala827Val | –/18 | –/20 | –/89 | 1/90 | 1/107 | 1/110 |
| Exon . | Nucleotide change . | Protein change . | Finnish CRC probands . | Finnish controls . | Dutch/Norwegian CRC probands . | Dutch controls . | United Kingdom CRC probands . | United Kingdom controls . | Danish CRC probands . | Danish controls . | Combined CRC probands . | Combined controls . | Wu et al. (13) CRC probands . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 | T to C | Val27Ala | –/109 | –/112 | –/155 | –/92 | –/264 | –/204 | 1/258 | ||||
| 4 | G to A | Glu109Lys | –/18 | –/20 | –/155 | –/92 | –/173 | –/112 | 2/258 | ||||
| 5 | G to T | Ala137Ser | –/18 | –/20 | 1/142 | –/71 | 1/160 | –/91 | |||||
| 9 | T to G | Leu410Arg | –/109 | –/112 | 1/154 | –/114 | 1/263 | –/226 | 2/258 | ||||
| 10 | T to G | Phe438Cys | –/18 | –/20 | 1/154 | –/104 | 1/172 | –/124 | |||||
| 11 | A to G | Ser610Gly | 1/300 | –/373 | 1/155 | –/52 | 2/418 | 1/208 | 1/97 | –/95 | 5/970 | 1/728 | 3/258 |
| 11 | C to T | Pro640Ser | 3/300 | 3/373 | 3/150 | –/52 | 5/418 | 2/208 | 1/97 | 2/95 | 12/965 | 7/728 | 1/258 |
| 11 | C to G | Pro640Ala | 1/300 | 1/373 | 1/150 | 1/52 | 3/418 | 2/208 | 2/97 | –/95 | 7/965 | 4/730 | 1/258 |
| 11 | C to T | Asp661Asp | –/18 | –/20 | 2/150 | –/52 | 2/168 | –/72 | |||||
| 13 | IVS12-1 | G to C | –/83 | –/504 | 1/149 | 3/200 | 1/232 | 3/704 | 1/258 | ||||
| 13 | IVS12-1 | G to A | –/83 | 1/504 | –/149 | –/200 | –/232 | 1/704 | |||||
| 13 | G to A | Gly759Glu | 3/109 | 11/112 | 1/149 | 1/200 | 4/258 | 12/312 | 2/258 | ||||
| 13 | C to T | Pro770Leu | –/109 | –/112 | –/149 | –/200 | –/258 | –/312 | 1/258 | ||||
| 14 | C to T | Ala827Val | –/18 | –/20 | –/89 | 1/90 | 1/107 | 1/110 |