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Table 1

Impact of ERBB2 expression and inhibition on the gene expression profile of Daoy xenografts

The expression of the 10 genes deregulated by ERBB2 overexpression in Daoy cells in culture was investigated in vivo using Affymetrix array analysis of Daoy.V and Daoy.2 xenografts. The first column lists the gene names. The second column indicates the mean (±SE) fold difference in expression of each gene between Daoy.2 versus Daoy.V xenografts from three independent experiments. Genes whose expression was significantly up-regulated by ERBB2 overexpression are shown above the dotted line. The third column compares the expression of each gene in Daoy.2 xenografts taken from animals treated with oral OSI-774 (100 mg/kg/twice a day) versus vehicle only. Note, only genes whose expression was significantly up-regulated by ERBB2 overexpression were down-regulated by the ERBB2 inhibitor.

Daoy.2:Daoy.VDaoy.2 + OSI-774:Daoy.2
Fold (±SE)PFold (±SE)P
Gene     
OSF-2 224.6 (±1.1)  <0.0001 0.66 (±0.04) 0.001 
S100A4 3.11 (±0.14) 0.006 0.75 (±0.01) 0.008 
RANTES 2.10 (±0.27) 0.01 0.46 (±0.06) 0.02 
p78 1.36 (±0.06) 0.02 0.38 (±0.11) 0.01 
p56 1.26 (±0.01) <0.0001 0.55 (±0.04) 0.005 
Metallothionein If 1.01 (±0.6) NS 1.38 (±0.26) NS 
MAPK KKK4 1.10 (±0.12) NS 1.14 (±0.16) NS 
MEK5 0.97 (±0.35) NS 0.94 (±0.10) NS 
PCDH7 0.82 (±0.08) NS 0.91 (±0.06) NS 
IGFBP5 0.88 (±0.03) NS 0.99 (±0.20) NS 
Daoy.2:Daoy.VDaoy.2 + OSI-774:Daoy.2
Fold (±SE)PFold (±SE)P
Gene     
OSF-2 224.6 (±1.1)  <0.0001 0.66 (±0.04) 0.001 
S100A4 3.11 (±0.14) 0.006 0.75 (±0.01) 0.008 
RANTES 2.10 (±0.27) 0.01 0.46 (±0.06) 0.02 
p78 1.36 (±0.06) 0.02 0.38 (±0.11) 0.01 
p56 1.26 (±0.01) <0.0001 0.55 (±0.04) 0.005 
Metallothionein If 1.01 (±0.6) NS 1.38 (±0.26) NS 
MAPK KKK4 1.10 (±0.12) NS 1.14 (±0.16) NS 
MEK5 0.97 (±0.35) NS 0.94 (±0.10) NS 
PCDH7 0.82 (±0.08) NS 0.91 (±0.06) NS 
IGFBP5 0.88 (±0.03) NS 0.99 (±0.20) NS 
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