Five-year DDFS according to Cox-2 expression level
| Clinicopathological parameter . | Cox-2 score . | n (%) . | DDFS (95% CI) . | P a . |
|---|---|---|---|---|
| Age <50 yr | 0–1 | 271 (64.8) | 79 (74–84) | NS;b 0.058 |
| 2 –3 | 147 (35.2) | 71 (64–79) | ||
| Age ≥50 yr | 0–1 | 716 (61.8) | 85 (82–88) | <0.0001 |
| 2–3 | 442 (38.2) | 74 (69–78) | ||
| Size ≤2 cm | 0–1 | 606 (67.8) | 89 (86–91) | 0.013 |
| 2–3 | 288 (32.2) | 83 (79–88) | ||
| Size >2 cm | 0–1 | 325 (54.1) | 72 (67–77) | NS; 0.052 |
| 2–3 | 276 (45.9) | 64 (58–70) | ||
| Node negative | 0–1 | 652 (66.3) | 90 (88–92) | 0.011 |
| 2–3 | 331 (33.7) | 86 (82–90) | ||
| Node positive | 0–1 | 299 (56.4) | 69 (64–74) | 0.006 |
| 2–3 | 231 (43.6) | 56 (49–63) | ||
| Grade 1c | 0–1 | 136 (74.3) | 96 (93–100) | 0.037 |
| 2–3 | 47 (25.7) | 91 (82–100) | ||
| Grade 2c | 0–1 | 311 (63.2) | 78 (74–83) | 0.009 |
| 2–3 | 181 (36.8) | 70 (63–77) | ||
| Grade 3c | 0–1 | 136 (47.9) | 69 (61–77) | NS; 0.543 |
| 2–3 | 148 (52.1) | 64 (55–72) | ||
| Ductal | 0–1 | 694 (60.1) | 81 (78–84) | <0.0001 |
| 2–3 | 461 (39.9) | 70 (66–75) | ||
| Lobular | 0–1 | 177 (70.5) | 87 (82–92) | NS; 0.232 |
| 2–3 | 74 (29.5) | 81 (71–91) | ||
| Special | 0–1 | 108 (69.2) | 94 (89–99) | NS; 0.396 |
| 2–3 | 48 (30.8) | 91 (83–100) | ||
| ER positive | 0–1 | 658 (66.6) | 86 (84–89) | <0.0001 |
| 2–3 | 330 (33.4) | 76 (72–81) | ||
| ER negative | 0–1 | 213 (47.7) | 70 (64–77) | NS; 0.396 |
| 2–3 | 234 (52.3) | 68 (62–74) | ||
| PgR positive | 0–1 | 537 (68.3) | 88 (86–91) | 0.002 |
| 2–3 | 249 (31.7) | 80 (74–85) | ||
| PgR negative | 0–1 | 329 (51.2) | 73 (68–78) | NS; 0.071 |
| 2–3 | 314 (48.8) | 67 (62–73) | ||
| Ki-67 <20% | 0–1 | 563 (67.0) | 87 (84–90) | 0.001 |
| 2–3 | 277 (33.0) | 77 (72–82) | ||
| Ki-67 ≥20% | 0–1 | 225 (46.0) | 71 (64–77) | NS; 0.097 |
| 2–3 | 264 (54.0) | 67 (61–73) | ||
| p53 negative/low | 0–1 | 679 (63.5) | 85 (82–88) | <0.0001 |
| 2–3 | 391 (36.5) | 74 (70–79) | ||
| p53 high | 0–1 | 99 (40.9) | 64 (54–74) | NS; 0.842 |
| 2–3 | 143 (59.1) | 68 (60–76) | ||
| HER-2 negative | 0–1 | 732 (63.3) | 86 (84–89) | <0.0001 |
| 2–3 | 425 (36.7) | 77 (73–81) | ||
| HER-2 positive | 0–1 | 130 (49.6) | 63 (54–71) | NS; 0.729 |
| 2–3 | 132 (50.4) | 59 (50–68) |
| Clinicopathological parameter . | Cox-2 score . | n (%) . | DDFS (95% CI) . | P a . |
|---|---|---|---|---|
| Age <50 yr | 0–1 | 271 (64.8) | 79 (74–84) | NS;b 0.058 |
| 2 –3 | 147 (35.2) | 71 (64–79) | ||
| Age ≥50 yr | 0–1 | 716 (61.8) | 85 (82–88) | <0.0001 |
| 2–3 | 442 (38.2) | 74 (69–78) | ||
| Size ≤2 cm | 0–1 | 606 (67.8) | 89 (86–91) | 0.013 |
| 2–3 | 288 (32.2) | 83 (79–88) | ||
| Size >2 cm | 0–1 | 325 (54.1) | 72 (67–77) | NS; 0.052 |
| 2–3 | 276 (45.9) | 64 (58–70) | ||
| Node negative | 0–1 | 652 (66.3) | 90 (88–92) | 0.011 |
| 2–3 | 331 (33.7) | 86 (82–90) | ||
| Node positive | 0–1 | 299 (56.4) | 69 (64–74) | 0.006 |
| 2–3 | 231 (43.6) | 56 (49–63) | ||
| Grade 1c | 0–1 | 136 (74.3) | 96 (93–100) | 0.037 |
| 2–3 | 47 (25.7) | 91 (82–100) | ||
| Grade 2c | 0–1 | 311 (63.2) | 78 (74–83) | 0.009 |
| 2–3 | 181 (36.8) | 70 (63–77) | ||
| Grade 3c | 0–1 | 136 (47.9) | 69 (61–77) | NS; 0.543 |
| 2–3 | 148 (52.1) | 64 (55–72) | ||
| Ductal | 0–1 | 694 (60.1) | 81 (78–84) | <0.0001 |
| 2–3 | 461 (39.9) | 70 (66–75) | ||
| Lobular | 0–1 | 177 (70.5) | 87 (82–92) | NS; 0.232 |
| 2–3 | 74 (29.5) | 81 (71–91) | ||
| Special | 0–1 | 108 (69.2) | 94 (89–99) | NS; 0.396 |
| 2–3 | 48 (30.8) | 91 (83–100) | ||
| ER positive | 0–1 | 658 (66.6) | 86 (84–89) | <0.0001 |
| 2–3 | 330 (33.4) | 76 (72–81) | ||
| ER negative | 0–1 | 213 (47.7) | 70 (64–77) | NS; 0.396 |
| 2–3 | 234 (52.3) | 68 (62–74) | ||
| PgR positive | 0–1 | 537 (68.3) | 88 (86–91) | 0.002 |
| 2–3 | 249 (31.7) | 80 (74–85) | ||
| PgR negative | 0–1 | 329 (51.2) | 73 (68–78) | NS; 0.071 |
| 2–3 | 314 (48.8) | 67 (62–73) | ||
| Ki-67 <20% | 0–1 | 563 (67.0) | 87 (84–90) | 0.001 |
| 2–3 | 277 (33.0) | 77 (72–82) | ||
| Ki-67 ≥20% | 0–1 | 225 (46.0) | 71 (64–77) | NS; 0.097 |
| 2–3 | 264 (54.0) | 67 (61–73) | ||
| p53 negative/low | 0–1 | 679 (63.5) | 85 (82–88) | <0.0001 |
| 2–3 | 391 (36.5) | 74 (70–79) | ||
| p53 high | 0–1 | 99 (40.9) | 64 (54–74) | NS; 0.842 |
| 2–3 | 143 (59.1) | 68 (60–76) | ||
| HER-2 negative | 0–1 | 732 (63.3) | 86 (84–89) | <0.0001 |
| 2–3 | 425 (36.7) | 77 (73–81) | ||
| HER-2 positive | 0–1 | 130 (49.6) | 63 (54–71) | NS; 0.729 |
| 2–3 | 132 (50.4) | 59 (50–68) |