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Table 2

Five-year DDFS according to Cox-2 expression level

Clinicopathological parameterCox-2 scoren (%)DDFS (95% CI)P              a
Age <50 yr 0–1 271 (64.8) 79 (74–84) NS;b 0.058 
 2 –3 147 (35.2) 71 (64–79)  
Age ≥50 yr 0–1 716 (61.8) 85 (82–88) <0.0001 
 2–3 442 (38.2) 74 (69–78)  
     
Size ≤2 cm 0–1 606 (67.8) 89 (86–91) 0.013 
 2–3 288 (32.2) 83 (79–88)  
     
Size >2 cm 0–1 325 (54.1) 72 (67–77) NS; 0.052 
 2–3 276 (45.9) 64 (58–70)  
Node negative 0–1 652 (66.3) 90 (88–92) 0.011 
 2–3 331 (33.7) 86 (82–90)  
Node positive 0–1 299 (56.4) 69 (64–74) 0.006 
 2–3 231 (43.6) 56 (49–63)  
     
Grade 1c 0–1 136 (74.3) 96 (93–100) 0.037 
 2–3 47 (25.7) 91 (82–100)  
Grade 2c 0–1 311 (63.2) 78 (74–83) 0.009 
 2–3 181 (36.8) 70 (63–77)  
Grade 3c 0–1 136 (47.9) 69 (61–77) NS; 0.543 
 2–3 148 (52.1) 64 (55–72)  
     
Ductal 0–1 694 (60.1) 81 (78–84) <0.0001 
 2–3 461 (39.9) 70 (66–75)  
Lobular 0–1 177 (70.5) 87 (82–92) NS; 0.232 
 2–3 74 (29.5) 81 (71–91)  
Special 0–1 108 (69.2) 94 (89–99) NS; 0.396 
 2–3 48 (30.8) 91 (83–100)  
     
ER positive 0–1 658 (66.6) 86 (84–89) <0.0001 
 2–3 330 (33.4) 76 (72–81)  
ER negative 0–1 213 (47.7) 70 (64–77) NS; 0.396 
 2–3 234 (52.3) 68 (62–74)  
     
PgR positive 0–1 537 (68.3) 88 (86–91) 0.002 
 2–3 249 (31.7) 80 (74–85)  
PgR negative 0–1 329 (51.2) 73 (68–78) NS; 0.071 
 2–3 314 (48.8) 67 (62–73)  
     
Ki-67 <20% 0–1 563 (67.0) 87 (84–90) 0.001 
 2–3 277 (33.0) 77 (72–82)  
Ki-67 ≥20% 0–1 225 (46.0) 71 (64–77) NS; 0.097 
 2–3 264 (54.0) 67 (61–73)  
     
p53 negative/low 0–1 679 (63.5) 85 (82–88) <0.0001 
 2–3 391 (36.5) 74 (70–79)  
p53 high 0–1 99 (40.9) 64 (54–74) NS; 0.842 
 2–3 143 (59.1) 68 (60–76)  
     
HER-2 negative 0–1 732 (63.3) 86 (84–89) <0.0001 
 2–3 425 (36.7) 77 (73–81)  
HER-2 positive 0–1 130 (49.6) 63 (54–71) NS; 0.729 
 2–3 132 (50.4) 59 (50–68)  
Clinicopathological parameterCox-2 scoren (%)DDFS (95% CI)P              a
Age <50 yr 0–1 271 (64.8) 79 (74–84) NS;b 0.058 
 2 –3 147 (35.2) 71 (64–79)  
Age ≥50 yr 0–1 716 (61.8) 85 (82–88) <0.0001 
 2–3 442 (38.2) 74 (69–78)  
     
Size ≤2 cm 0–1 606 (67.8) 89 (86–91) 0.013 
 2–3 288 (32.2) 83 (79–88)  
     
Size >2 cm 0–1 325 (54.1) 72 (67–77) NS; 0.052 
 2–3 276 (45.9) 64 (58–70)  
Node negative 0–1 652 (66.3) 90 (88–92) 0.011 
 2–3 331 (33.7) 86 (82–90)  
Node positive 0–1 299 (56.4) 69 (64–74) 0.006 
 2–3 231 (43.6) 56 (49–63)  
     
Grade 1c 0–1 136 (74.3) 96 (93–100) 0.037 
 2–3 47 (25.7) 91 (82–100)  
Grade 2c 0–1 311 (63.2) 78 (74–83) 0.009 
 2–3 181 (36.8) 70 (63–77)  
Grade 3c 0–1 136 (47.9) 69 (61–77) NS; 0.543 
 2–3 148 (52.1) 64 (55–72)  
     
Ductal 0–1 694 (60.1) 81 (78–84) <0.0001 
 2–3 461 (39.9) 70 (66–75)  
Lobular 0–1 177 (70.5) 87 (82–92) NS; 0.232 
 2–3 74 (29.5) 81 (71–91)  
Special 0–1 108 (69.2) 94 (89–99) NS; 0.396 
 2–3 48 (30.8) 91 (83–100)  
     
ER positive 0–1 658 (66.6) 86 (84–89) <0.0001 
 2–3 330 (33.4) 76 (72–81)  
ER negative 0–1 213 (47.7) 70 (64–77) NS; 0.396 
 2–3 234 (52.3) 68 (62–74)  
     
PgR positive 0–1 537 (68.3) 88 (86–91) 0.002 
 2–3 249 (31.7) 80 (74–85)  
PgR negative 0–1 329 (51.2) 73 (68–78) NS; 0.071 
 2–3 314 (48.8) 67 (62–73)  
     
Ki-67 <20% 0–1 563 (67.0) 87 (84–90) 0.001 
 2–3 277 (33.0) 77 (72–82)  
Ki-67 ≥20% 0–1 225 (46.0) 71 (64–77) NS; 0.097 
 2–3 264 (54.0) 67 (61–73)  
     
p53 negative/low 0–1 679 (63.5) 85 (82–88) <0.0001 
 2–3 391 (36.5) 74 (70–79)  
p53 high 0–1 99 (40.9) 64 (54–74) NS; 0.842 
 2–3 143 (59.1) 68 (60–76)  
     
HER-2 negative 0–1 732 (63.3) 86 (84–89) <0.0001 
 2–3 425 (36.7) 77 (73–81)  
HER-2 positive 0–1 130 (49.6) 63 (54–71) NS; 0.729 
 2–3 132 (50.4) 59 (50–68)  
a

Log-rank test or log-rank test for a trend.

b

NS, not significant.

c

Ductal type only.

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