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Table 1

Association of elevated Cox-2 immunopositivity (score 2–3) with clinicopathological parameters

Clinicopathological parameterCox-2 staining (positive/total)Cox-2 positive (%)Pa (odds ratio)
Age at diagnosis (yr)    
 <50 147/418 35.2 NS;b 0.167 
 ≥50 442/1158 38.2 (0.88; 0.69–1.12) 
Tumor size (cm)    
 ≤2 cm 288/894 32.2 <0.0001 
 >2 cm 276/601 45.9 (0.56; 0.45–0.70) 
Axillary node status    
 Negative 331/983 33.7 =0.0001 
 Positive 231/530 43.6 (0.66; 0.53–0.82) 
Histologic gradec    
 I 47/183 25.7 <0.0001 
 II 181/492 36.8  
 III 148/284 52.1  
Histologic type    
 Ductal 461/1155 39.9 =0.0017 
 Lobular 74/251 29.5  
 Special 48/156 30.8  
ER    
 Negative 234/447 52.3 <0.0001 
 Positive 330/988 33.4 (0.46; 0.36–0.58) 
PgR    
 Negative 314/643 48.8 <0.0001 
 Positive 249/786 31.7 (0.49; 0.39–0.61) 
Tumor proliferation    
 Ki-67 <20% 277/840 33.0 <0.0001 
 Ki-67 ≥20% 264/489 54.0 (0.42; 0.33–0.53) 
p53 expression    
 Negative/Low 391/1070 36.5 <0.0001 
 High 143/242 59.1 (0.40; 0.30–0.54) 
HER-2 oncogene amplification    
 Negative 425/1157 36.7 <0.0001 
 Positive 132/262 50.4 (0.57; 0.43–0.76) 
Clinicopathological parameterCox-2 staining (positive/total)Cox-2 positive (%)Pa (odds ratio)
Age at diagnosis (yr)    
 <50 147/418 35.2 NS;b 0.167 
 ≥50 442/1158 38.2 (0.88; 0.69–1.12) 
Tumor size (cm)    
 ≤2 cm 288/894 32.2 <0.0001 
 >2 cm 276/601 45.9 (0.56; 0.45–0.70) 
Axillary node status    
 Negative 331/983 33.7 =0.0001 
 Positive 231/530 43.6 (0.66; 0.53–0.82) 
Histologic gradec    
 I 47/183 25.7 <0.0001 
 II 181/492 36.8  
 III 148/284 52.1  
Histologic type    
 Ductal 461/1155 39.9 =0.0017 
 Lobular 74/251 29.5  
 Special 48/156 30.8  
ER    
 Negative 234/447 52.3 <0.0001 
 Positive 330/988 33.4 (0.46; 0.36–0.58) 
PgR    
 Negative 314/643 48.8 <0.0001 
 Positive 249/786 31.7 (0.49; 0.39–0.61) 
Tumor proliferation    
 Ki-67 <20% 277/840 33.0 <0.0001 
 Ki-67 ≥20% 264/489 54.0 (0.42; 0.33–0.53) 
p53 expression    
 Negative/Low 391/1070 36.5 <0.0001 
 High 143/242 59.1 (0.40; 0.30–0.54) 
HER-2 oncogene amplification    
 Negative 425/1157 36.7 <0.0001 
 Positive 132/262 50.4 (0.57; 0.43–0.76) 
a

χ2 test.

b

NS, not significant.

c

Ductal type only.

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