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Table 1

Correlation between results of preoperative peripheral blood RT-PCR for PSA and hK2 assays with categorical clinical and pathologic characteristics of 224 patients undergoing radical prostatectomy for clinically localized prostate cancer

No. of patients (%)RT-PCR-PSART-PCR-hK2-LRT-PCR-hK2-U
PositiveP              aPositiveP              aPositiveP              a
Total 224 (100%) 54 (24)  57 (25)  58 (26)  
Clinical stage        
 T1 103 (46) 27 (26)  21 (20)  29 (28)  
 T2 121 (54) 27 (22) 0.533 36 (30) 0.125 29 (24) 0.541 
Biopsy Gleason sum        
 2–6 154 (69) 31 (30)  34 (22)  33 (21)  
 7–10 70 (31) 8 (18) 0.158 24 (34) 0.071 24 (34) 0.050 
RPb extraprostatic extensionc        
 Negative 156 (71) 36 (23)  34 (22)  38 (24)  
 Positive 63 (29) 16 (25) 0.728 19 (30) 0.223 16 (25) 0.864 
RP seminal vesicle involvement        
 Negative 201 (92) 48 (24)  46 (23)  47 (23)  
 Positive 18 (8) 4 (22) 1.000 7 (39) 0.152 7 (39) 0.158 
RP surgical margin        
 Negative 181 (83) 43 (24)  40 (22)  43 (24)  
 Positive 38 (17) 9 (24) 1.000 13 (34) 0.144 11 (29) 0.536 
RP Gleason sum        
 2–6 116 (53) 28 (24)  21 (18)  23 (20)  
 7–10 103 (47) 24 (23) 1.000 32 (31) 0.028 31 (30) 0.086 
RP lymph node metastases        
 Negative 216 (96) 52 (24)  51 (24)  54 (25)  
 Positive 8 (4) 2 (25) 1.000 6 (75) 0.004 4 (50) 0.210 
RP DNA ploidyd        
 Diploid 106 (56) 26 (25)  24 (23)  28 (26)  
 Aneuploid 82 (44) 20 (24) 1.000 22 (27) 0.608 17 (21) 0.393 
No. of patients (%)RT-PCR-PSART-PCR-hK2-LRT-PCR-hK2-U
PositiveP              aPositiveP              aPositiveP              a
Total 224 (100%) 54 (24)  57 (25)  58 (26)  
Clinical stage        
 T1 103 (46) 27 (26)  21 (20)  29 (28)  
 T2 121 (54) 27 (22) 0.533 36 (30) 0.125 29 (24) 0.541 
Biopsy Gleason sum        
 2–6 154 (69) 31 (30)  34 (22)  33 (21)  
 7–10 70 (31) 8 (18) 0.158 24 (34) 0.071 24 (34) 0.050 
RPb extraprostatic extensionc        
 Negative 156 (71) 36 (23)  34 (22)  38 (24)  
 Positive 63 (29) 16 (25) 0.728 19 (30) 0.223 16 (25) 0.864 
RP seminal vesicle involvement        
 Negative 201 (92) 48 (24)  46 (23)  47 (23)  
 Positive 18 (8) 4 (22) 1.000 7 (39) 0.152 7 (39) 0.158 
RP surgical margin        
 Negative 181 (83) 43 (24)  40 (22)  43 (24)  
 Positive 38 (17) 9 (24) 1.000 13 (34) 0.144 11 (29) 0.536 
RP Gleason sum        
 2–6 116 (53) 28 (24)  21 (18)  23 (20)  
 7–10 103 (47) 24 (23) 1.000 32 (31) 0.028 31 (30) 0.086 
RP lymph node metastases        
 Negative 216 (96) 52 (24)  51 (24)  54 (25)  
 Positive 8 (4) 2 (25) 1.000 6 (75) 0.004 4 (50) 0.210 
RP DNA ploidyd        
 Diploid 106 (56) 26 (25)  24 (23)  28 (26)  
 Aneuploid 82 (44) 20 (24) 1.000 22 (27) 0.608 17 (21) 0.393 
a

Fisher’s exact test.

b

RP, radical prostatectomy.

c

Radical prostatectomy extraprostatic extension, seminal vesicle involvement, margin status, and Gleason sum were unavailable for 5 patients, who did not undergo a prostatectomy because of grossly positive pelvic lymph nodes at the time of surgery.

d

Radical prostatectomy DNA ploidy was unavailable for 36 patients.

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