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Table 1

Incidences of neoplasia in Msh2−/−, Msh2−/−Rb+/−, and Rb+/− micea

NeoplasiaGenotypesA              bB              c
Msh2−/− (%)Msh2−/−Rb+/− (%)Rb+/− (%)
Lymphoma 75 (12/16) 68 (15/22) 0 (0/20) 0.7262  
Generalized lymphomad 56 (9/16) 18 (4/22) 0 (0/20) 0.0199  
Tumor of the small intestine 75 (9/12) 79 (11/14) 0 (0/18) 1.0000  
Tumor of the large intestine 33 (4/12) 29 (4/14) 0 (0/18) 1.0000  
Skin tumor 13 (2/16) 9 (2/22) 0 (0/20) 1.0000  
Soft tissue tumor 0 (0/16) 14 (3/22) 0 (0/20) 0.2489  
Melanotroph tumor of the pituitary 0 (0/12) 100 (16/16) 100 (20/20)  ND 
Tumor of the pituitary anterior lobe 0 (0/12) 25 (4/16) 26 (5/19)  1.0000 
C-cell thyroid carcinoma 0 (0/12) 87 (14/16) 94 (18/19)  0.5820 
Adrenal pheochromocytoma 0 (0/12) 69 (11/16) 74 (14/19)  1.0000 
NeoplasiaGenotypesA              bB              c
Msh2−/− (%)Msh2−/−Rb+/− (%)Rb+/− (%)
Lymphoma 75 (12/16) 68 (15/22) 0 (0/20) 0.7262  
Generalized lymphomad 56 (9/16) 18 (4/22) 0 (0/20) 0.0199  
Tumor of the small intestine 75 (9/12) 79 (11/14) 0 (0/18) 1.0000  
Tumor of the large intestine 33 (4/12) 29 (4/14) 0 (0/18) 1.0000  
Skin tumor 13 (2/16) 9 (2/22) 0 (0/20) 1.0000  
Soft tissue tumor 0 (0/16) 14 (3/22) 0 (0/20) 0.2489  
Melanotroph tumor of the pituitary 0 (0/12) 100 (16/16) 100 (20/20)  ND 
Tumor of the pituitary anterior lobe 0 (0/12) 25 (4/16) 26 (5/19)  1.0000 
C-cell thyroid carcinoma 0 (0/12) 87 (14/16) 94 (18/19)  0.5820 
Adrenal pheochromocytoma 0 (0/12) 69 (11/16) 74 (14/19)  1.0000 
a

Numbers in parentheses indicate number of mice with tumor/total number of mice.

b

A, Fisher’s P test Msh2−/−Rb+/−versus Msh2−/−.

c

B, Fisher’s P test Msh2−/−Rb+/−versus Rb+/−.

d

Lymphomas involving more than three tissues were considered as generalized.

e

ND, not determined.

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