Regulation of VHL target genes by hypoxia
| Regulation by hypoxia . | . | . | . | |||
|---|---|---|---|---|---|---|
| Gene/cell lines . | EJ-28 . | HBL-100 . | 293 . | |||
| Cyclin D1 | NI (1.1)a | NM | NI (1.0) | |||
| CDK6 | NI (1.1) | NI (1.2) | NM | |||
| ITGB8 | NI (1.0) | NI (1.2) | NM | |||
| CD59 | NI (1.5) | NI (1.2) | NI (0.8) | |||
| COL8A1 | NM | NM | NM | |||
| IL-6 | NM | NM | NM | |||
| VEGF | +++ | ++ | + | |||
| LRP1 | ND | + | NM | |||
| PAI-1 | + | + | NM | |||
| Regulation by hypoxia . | . | . | . | |||
|---|---|---|---|---|---|---|
| Gene/cell lines . | EJ-28 . | HBL-100 . | 293 . | |||
| Cyclin D1 | NI (1.1)a | NM | NI (1.0) | |||
| CDK6 | NI (1.1) | NI (1.2) | NM | |||
| ITGB8 | NI (1.0) | NI (1.2) | NM | |||
| CD59 | NI (1.5) | NI (1.2) | NI (0.8) | |||
| COL8A1 | NM | NM | NM | |||
| IL-6 | NM | NM | NM | |||
| VEGF | +++ | ++ | + | |||
| LRP1 | ND | + | NM | |||
| PAI-1 | + | + | NM | |||
Key. − = NI, not induced (fold change); + = 2–3.9-fold induction; ++ = 4–7.9-fold induction; +++ = 8–15.9-fold induction; NM, not detected at measurable level; ND, not done.