Results from methylation and LOH studies in medulloblastomaa
For methylation studies, % Top band is the proportion of total signal present in the band representing methylation inclusive of N2–4. For LOH studies, YNZ22 and D17S849 are chromosome arm 17p markers.
| Sample . | % Top band . | LOH YNZ . | LOH 849 . | Outcome . | Risk group . |
|---|---|---|---|---|---|
| M 01 Tumor | 56% | − | ND | Dead | Poor |
| M 02 Tumor | 66% | − | ND | Dead | Poor |
| M 04 Tumor | 0 | − | − | Alive | Good |
| M 07 Tumor | 0 | + | + | Dead | Good |
| M 08 Tumor | 1% | + | + | Dead | Good |
| M 11 Tumor | 100% | − | − | Dead | Poor |
| M 12 Tumor | 62% | + | + | Dead | Good |
| M 13 Tumor | 100% | − | − | Alive | Good |
| M 19 Tumor | 0 | − | − | Alive | Good |
| M 20 Tumor | 100% | + | + | Dead | Poor |
| M 22 Tumor | 100% | − | − | Alive | Good |
| M 26 Tumor | 100% | + | NI | Dead | Good |
| M 28 Tumor | 62% | NI | + | Dead | Poor |
| M 31 Tumor | 50% | − | NI | Alive | Poor |
| M 33 Tumor | 100% | + | + | Dead | Poor |
| M 34 Tumor | 67% | + | + | Dead | Good |
| M 35 Tumor | 0 | + | NI | Alive | Good |
| M 37 Tumor | 100% | − | − | Dead | Good |
| M 38 Tumor | 100% | NI | − | Dead | Poor |
| M 42 Tumor | 0 | − | − | Alive | Good |
| M 44 Tumor | 100% | − | − | Alive | Good |
| M 45 Tumor | 100% | − | − | Dead | Poor |
| M 46 Tumor | 100% | − | − | Alive | Good |
| M 48 Tumor | 100% | − | − | Dead | Good |
| M 49 Tumor | 49% | − | − | Dead | Poor |
| M 50 Tumor | 0 | + | + | Alive | Poor |
| M 52 Tumor | 0 | + | ND | Alive | Good |
| M 53 Tumor | 100% | − | − | Dead | Poor |
| M 54 Tumor | 0 | + | + | Alive | Good |
| M 55 Tumor | 0 | − | − | Alive | Poor |
| M 56 Tumor | 7% | + | + | Alive | Good |
| M 57 Tumor | 18% | NI | − | Dead | Poor |
| M 58 Tumor | 53% | − | − | Alive | Good |
| M 59 Tumor | 100% | NI | + | Alive | Good |
| M 61 Tumor | 0 | NI | + | Alive | Good |
| M 63 Tumor | 100% | − | − | Dead | Good |
| NB 1 | 14% | ||||
| NB 2 | 14% | ||||
| NB 3 | 3% | ||||
| NB 4 | 0 | ||||
| NB 5 | 33% | ||||
| NB 6 | 10% | ||||
| NB 7 | 25% | ||||
| NB 8 | 25% | ||||
| NB 9 | 21% | ||||
| NB 10 | 11% | ||||
| NB 11 | 3% | ||||
| NB 12 | 16% |
| Sample . | % Top band . | LOH YNZ . | LOH 849 . | Outcome . | Risk group . |
|---|---|---|---|---|---|
| M 01 Tumor | 56% | − | ND | Dead | Poor |
| M 02 Tumor | 66% | − | ND | Dead | Poor |
| M 04 Tumor | 0 | − | − | Alive | Good |
| M 07 Tumor | 0 | + | + | Dead | Good |
| M 08 Tumor | 1% | + | + | Dead | Good |
| M 11 Tumor | 100% | − | − | Dead | Poor |
| M 12 Tumor | 62% | + | + | Dead | Good |
| M 13 Tumor | 100% | − | − | Alive | Good |
| M 19 Tumor | 0 | − | − | Alive | Good |
| M 20 Tumor | 100% | + | + | Dead | Poor |
| M 22 Tumor | 100% | − | − | Alive | Good |
| M 26 Tumor | 100% | + | NI | Dead | Good |
| M 28 Tumor | 62% | NI | + | Dead | Poor |
| M 31 Tumor | 50% | − | NI | Alive | Poor |
| M 33 Tumor | 100% | + | + | Dead | Poor |
| M 34 Tumor | 67% | + | + | Dead | Good |
| M 35 Tumor | 0 | + | NI | Alive | Good |
| M 37 Tumor | 100% | − | − | Dead | Good |
| M 38 Tumor | 100% | NI | − | Dead | Poor |
| M 42 Tumor | 0 | − | − | Alive | Good |
| M 44 Tumor | 100% | − | − | Alive | Good |
| M 45 Tumor | 100% | − | − | Dead | Poor |
| M 46 Tumor | 100% | − | − | Alive | Good |
| M 48 Tumor | 100% | − | − | Dead | Good |
| M 49 Tumor | 49% | − | − | Dead | Poor |
| M 50 Tumor | 0 | + | + | Alive | Poor |
| M 52 Tumor | 0 | + | ND | Alive | Good |
| M 53 Tumor | 100% | − | − | Dead | Poor |
| M 54 Tumor | 0 | + | + | Alive | Good |
| M 55 Tumor | 0 | − | − | Alive | Poor |
| M 56 Tumor | 7% | + | + | Alive | Good |
| M 57 Tumor | 18% | NI | − | Dead | Poor |
| M 58 Tumor | 53% | − | − | Alive | Good |
| M 59 Tumor | 100% | NI | + | Alive | Good |
| M 61 Tumor | 0 | NI | + | Alive | Good |
| M 63 Tumor | 100% | − | − | Dead | Good |
| NB 1 | 14% | ||||
| NB 2 | 14% | ||||
| NB 3 | 3% | ||||
| NB 4 | 0 | ||||
| NB 5 | 33% | ||||
| NB 6 | 10% | ||||
| NB 7 | 25% | ||||
| NB 8 | 25% | ||||
| NB 9 | 21% | ||||
| NB 10 | 11% | ||||
| NB 11 | 3% | ||||
| NB 12 | 16% |
M, medulloblastoma; NB, normal brain; +, LOH; −, retained heterozygosity; NI, noninformative because of constitutional homozygosity; ND, not determined.