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Table 2

Quantification of AR, ERα, ERβ, and PGR in human prostate tissues

The expression levels are displayed as a ratio between the target gene and a reference gene (RPLP0) to correct for variation in the amounts of RNA as well as of that specific marker for epithelial cells (KRT18) and/or stroma cells (VIM) according to the cell-type specificity expression of the target gene. RPLP0, KRT18, and VIM denote acidic ribosomal phosphoprotein P0, cytokeratin 18, and vimentin.
SamplesNormala (mean ± SD)Clinically localized (mean ± SD)Hormone-refractoryb (mean ± SD)P              c
AR:RPLP0 1.00 ± 0.15 1.15 ± 0.54 7.38 ± 7.23 <0.001 
AR:KRT18 1.00 ± 0.15 1.00 ± 0.38 12.31 ± 13.1 <0.001 
ERα:RPLP0 1.00 ± 0.20 0.71 ± 0.52 0.58 ± 0.54 NSd (P = 0.16) 
ERα:VIM 1.00 ± 0.38 1.29 ± 0.65 0.59 ± 0.45 0.02 
ERβ:RPLP0 1.00 ± 0.20 0.47 ± 0.46 0.38 ± 0.45 0.02 
ERβ:KRT18 1.00 ± 0.31 0.38 ± 0.39 0.62 ± 0.64 NS (P = 0.07) 
ERβ:VIM 1.00 ± 0.23 1.16 ± 1.00 0.52 ± 0.48 NS (P = 0.23) 
PGR:RPLP0 1.00 ± 0.74 0.42 ± 0.38 1.30 ± 1.25 NS (P = 0.18) 
PGR:VIM 1.00 ± 1.00 0.90 ± 0.65 1.90 ± 2.00 NS (P = 0.67) 
The expression levels are displayed as a ratio between the target gene and a reference gene (RPLP0) to correct for variation in the amounts of RNA as well as of that specific marker for epithelial cells (KRT18) and/or stroma cells (VIM) according to the cell-type specificity expression of the target gene. RPLP0, KRT18, and VIM denote acidic ribosomal phosphoprotein P0, cytokeratin 18, and vimentin.
SamplesNormala (mean ± SD)Clinically localized (mean ± SD)Hormone-refractoryb (mean ± SD)P              c
AR:RPLP0 1.00 ± 0.15 1.15 ± 0.54 7.38 ± 7.23 <0.001 
AR:KRT18 1.00 ± 0.15 1.00 ± 0.38 12.31 ± 13.1 <0.001 
ERα:RPLP0 1.00 ± 0.20 0.71 ± 0.52 0.58 ± 0.54 NSd (P = 0.16) 
ERα:VIM 1.00 ± 0.38 1.29 ± 0.65 0.59 ± 0.45 0.02 
ERβ:RPLP0 1.00 ± 0.20 0.47 ± 0.46 0.38 ± 0.45 0.02 
ERβ:KRT18 1.00 ± 0.31 0.38 ± 0.39 0.62 ± 0.64 NS (P = 0.07) 
ERβ:VIM 1.00 ± 0.23 1.16 ± 1.00 0.52 ± 0.48 NS (P = 0.23) 
PGR:RPLP0 1.00 ± 0.74 0.42 ± 0.38 1.30 ± 1.25 NS (P = 0.18) 
PGR:VIM 1.00 ± 1.00 0.90 ± 0.65 1.90 ± 2.00 NS (P = 0.67) 
a

The ratios for each type of analysis have been normalized in such a manner that the mean ratio of the normal prostate samples equals a value of 1.

b

The values for T101 were excluded from the calculation because they are inconsistent with those for the hormone refractory tumors.

c

Ps were calculated by the Kruscal-Wallis test or the Mann-Whitney U test.

d

NS, not significant.

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