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Table 1

In vitro response of rat C6 glioma cells expressing wild-type or mutant TKs to GCV or ACV

GCV IC50 μmRelative to TKACV IC50 μmRelative to TK
TK >20 
SR11 0.15 33 >3 
SR26 0.04 125 0.76 >26 
SR39 0.017 294 0.11 >182 
GCV IC50 μmRelative to TKACV IC50 μmRelative to TK
TK >20 
SR11 0.15 33 >3 
SR26 0.04 125 0.76 >26 
SR39 0.017 294 0.11 >182 
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