American Association for Cancer Research

Table 1

Plasma DNA: diagnoses; quantitations; presence of T-cell DNA; and hypermethylation of CDKN2A promoter

Patient	Cancer	DNA (ng/ml)	T cells^a	CDKN2A ^b
C1	Colorectal	167	−	−
C2	Angiosarcoma	19	ND^c	+
C3	NSCLC	100	−	ND
C4	Breast	66	−	−
C5	Breast	134	−	ND
C6	SCLC	33	−	ND
C7	Breast	170	−	ND
C8	Breast	83	−	+
C9	Ewing’s sarcoma	60	−	+
C10	Breast	20	ND	+
C11	NSCLC	84	ND	−
C12	Head and neck	10	ND	+
C13	Melanoma	20	ND	+
C14	Pancreas	1200	+	−
C15	Colorectal	67	−	−
C16	Colorectal	25	ND	ND
C17	Colorectal	50	ND	−
C18	Breast	38	ND	−
C19	Breast	90	−	−
C20	Pancreas	48	−	+
C21	HCC	84	−	−
C22	Urothel	168	−	−
C23	Breast	360	−	+
T1	NSCLC	550	−	+
T2	Colorectal	555	−	+
T3	Esophagus	833	−	+
T5	Stomach	500	+	−
T6	Colorectal	980	−	−
T7	Colorectal	38	ND	−
T8	Colorectal	34	ND	−

Patient	Cancer	DNA (ng/ml)	T cells^a	CDKN2A ^b
C1	Colorectal	167	−	−
C2	Angiosarcoma	19	ND^c	+
C3	NSCLC	100	−	ND
C4	Breast	66	−	−
C5	Breast	134	−	ND
C6	SCLC	33	−	ND
C7	Breast	170	−	ND
C8	Breast	83	−	+
C9	Ewing’s sarcoma	60	−	+
C10	Breast	20	ND	+
C11	NSCLC	84	ND	−
C12	Head and neck	10	ND	+
C13	Melanoma	20	ND	+
C14	Pancreas	1200	+	−
C15	Colorectal	67	−	−
C16	Colorectal	25	ND	ND
C17	Colorectal	50	ND	−
C18	Breast	38	ND	−
C19	Breast	90	−	−
C20	Pancreas	48	−	+
C21	HCC	84	−	−
C22	Urothel	168	−	−
C23	Breast	360	−	+
T1	NSCLC	550	−	+
T2	Colorectal	555	−	+
T3	Esophagus	833	−	+
T5	Stomach	500	+	−
T6	Colorectal	980	−	−
T7	Colorectal	38	ND	−
T8	Colorectal	34	ND	−

+ or −, presence or absence, respectively, of T-cell DNA in plasma samples.

+, hypermethylation of CDKN2A gene promoter; −,no hypermethylation detected.

ND, not done; NSCLC, non-mall cell lung cancer; SCLC, small cell lung cancer; HCC, hepatocellular carcinoma.