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Table 3

Effects of NIM on the development of tongue lesions in rats initiated by 4-NQO

Group no.TreatmentEffective no. of ratsaTongue lesionsSize distribution of SCCs (%) diameter (mm)
Incidence (%)Multiplicity (no./rat)
HPbDPPAPSCCHPDPPAPSCC<33–10<10
4-NQO alone 11 7 (63.6) 10 (90.9) 2 (22.2) 9 (81.8) 1.09 ± 1.04 2.18 ± 1.40 0.22 ± 0.44 1.00 ± 0.77 3 (27.3) 2 (18.1) 6 (54.5) 
4-NQO+ 150 ppm NIM 12 9 (75.0) 11 (91.7) 5 (41.7) 4 (33.3)c 1.50 ± 1.17 1.83 ± 1.19 0.42 ± 0.51 0.33 ± 0.49c 1 (25.0) 2 (50.0) 1 (25.0) 
4-NQO+ 300 ppm NIM 13 11 (84.6) 13 (100) 3 (23.1) 1 (7.7)d 1.23 ± 0.83 2.00 ± 1.00 0.23 ± 0.44 0.08 ± 0.28e 1 (100) 
4-NQO+ 600 ppm NIM 12 7 (58.3) 10 (83.3) 3 (25.0) 5 (41.7) 0.75 ± 0.75 1.08 ± 0.67 0.25 ± 0.45 0.50 ± 0.67 4 (66.7) 2 (33.3) 
Group no.TreatmentEffective no. of ratsaTongue lesionsSize distribution of SCCs (%) diameter (mm)
Incidence (%)Multiplicity (no./rat)
HPbDPPAPSCCHPDPPAPSCC<33–10<10
4-NQO alone 11 7 (63.6) 10 (90.9) 2 (22.2) 9 (81.8) 1.09 ± 1.04 2.18 ± 1.40 0.22 ± 0.44 1.00 ± 0.77 3 (27.3) 2 (18.1) 6 (54.5) 
4-NQO+ 150 ppm NIM 12 9 (75.0) 11 (91.7) 5 (41.7) 4 (33.3)c 1.50 ± 1.17 1.83 ± 1.19 0.42 ± 0.51 0.33 ± 0.49c 1 (25.0) 2 (50.0) 1 (25.0) 
4-NQO+ 300 ppm NIM 13 11 (84.6) 13 (100) 3 (23.1) 1 (7.7)d 1.23 ± 0.83 2.00 ± 1.00 0.23 ± 0.44 0.08 ± 0.28e 1 (100) 
4-NQO+ 600 ppm NIM 12 7 (58.3) 10 (83.3) 3 (25.0) 5 (41.7) 0.75 ± 0.75 1.08 ± 0.67 0.25 ± 0.45 0.50 ± 0.67 4 (66.7) 2 (33.3) 
a

Based on histological examination.

b

HP, hyperplasia; DP, dysplasia;PAP, squamous cell papilloma.

c

Significantly different from Group 1 (P < 0.05).

d

Significantly different from Group 1 (P < 0.0005).

e

Significantly different from Group 1 (P < 0.01).

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