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Table 2

Experimental details for rats given 4-NQO for 12 weeks followed by NIM for 14 weeksa

Group no.TreatmentNo. of rats (final)Body weight (g)·(final)Organ weight (g) (ratio to body weight × 10)Average water intakeAverage food intake
LiverKidneyWater (ml/day/kg body weight)4-NQO (mg/day/kg body weight)Diet (g/day/kg body weight)NIM (mg/day/kg body weight)
4-NQO alone 11 327 ± 39 9.1 ± 1.7 1.02 ± 0.08 72.4 ± 19.9 2.23 ± 0.40 42.3 ± 5.5 
    (27.6 ± 2.18) (3.15 ± 0.28)     
4-NQO+ 150 ppm NIM 12 349 ± 38 10.8 ± 2.3 1.12 ± 0.10 74.2 ± 21.1 2.29 ± 0.44 45.4 ± 5.1 6.8 ± 0.8 
    (29.7 ± 4.7) (3.24 ± 0.23)     
4-NQO+ 300 ppm NIM 13 365 ± 21 11.2 ± 0.9 1.16 ± 0.08 73.1 ± 20.5 2.25 ± 0.42 45.5 ± 5.4 13.6 ± 1.6 
    (30.7 ± 1.3) (3.20 ± 0.22)     
4-NQO+ 600 ppm NIM 12 351 ± 49 10.4 ± 2.4 1.12 ± 0.13 72.2 ± 19.8 2.22 ± 0.39 44.4 ± 5.6 30.0 ± 3.0 
    (30.4 ± 3.9) (3.24 ± 0.23)     
Water+ basal diet 388 ± 15 12.5 ± 1.0 1.20 ± 0.05 90.0 ± 24.5 43.8 ± 7.6 
    (32.2 ± 2.5) (3.09 ± 0.14)     
Water+ 600 ppm NIM 392 ± 13 11.2 ± 0.6 1.09 ± 0.04 86.5 ± 22.5 44.4 ± 6.5 26.0 ± 4.1 
    (28.7 ± 1.1) (2.77 ± 0.12)     
Group no.TreatmentNo. of rats (final)Body weight (g)·(final)Organ weight (g) (ratio to body weight × 10)Average water intakeAverage food intake
LiverKidneyWater (ml/day/kg body weight)4-NQO (mg/day/kg body weight)Diet (g/day/kg body weight)NIM (mg/day/kg body weight)
4-NQO alone 11 327 ± 39 9.1 ± 1.7 1.02 ± 0.08 72.4 ± 19.9 2.23 ± 0.40 42.3 ± 5.5 
    (27.6 ± 2.18) (3.15 ± 0.28)     
4-NQO+ 150 ppm NIM 12 349 ± 38 10.8 ± 2.3 1.12 ± 0.10 74.2 ± 21.1 2.29 ± 0.44 45.4 ± 5.1 6.8 ± 0.8 
    (29.7 ± 4.7) (3.24 ± 0.23)     
4-NQO+ 300 ppm NIM 13 365 ± 21 11.2 ± 0.9 1.16 ± 0.08 73.1 ± 20.5 2.25 ± 0.42 45.5 ± 5.4 13.6 ± 1.6 
    (30.7 ± 1.3) (3.20 ± 0.22)     
4-NQO+ 600 ppm NIM 12 351 ± 49 10.4 ± 2.4 1.12 ± 0.13 72.2 ± 19.8 2.22 ± 0.39 44.4 ± 5.6 30.0 ± 3.0 
    (30.4 ± 3.9) (3.24 ± 0.23)     
Water+ basal diet 388 ± 15 12.5 ± 1.0 1.20 ± 0.05 90.0 ± 24.5 43.8 ± 7.6 
    (32.2 ± 2.5) (3.09 ± 0.14)     
Water+ 600 ppm NIM 392 ± 13 11.2 ± 0.6 1.09 ± 0.04 86.5 ± 22.5 44.4 ± 6.5 26.0 ± 4.1 
    (28.7 ± 1.1) (2.77 ± 0.12)     
a

Values are means ± SD.

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