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Table 1

COX-2 immunohistochemical staining of tongue lesions in rats given 10 ppm 4-NQO in their drinking water for 24 weeks

Tongue lesionsIncidence (%)No. of lesions examinedStaining with COX-2 antibodya
No. of lesions (%)
±++++++
Hyperplasia 22 /33 (66.7) 29 14 (48.3) 14 (48.3) 1 (3.4) 
Dysplasia 21 /33 (63.6) 36 11 (30.6) 20 (55.6) 5 (13.9) 
Papilloma 10 /33 (30.3) 11 6 (54.5) 5 (45.5) 
SCC 11 /33 (33.3) 13 5 (38.5) 6 (46.2) 2 (15.4) 
Tongue lesionsIncidence (%)No. of lesions examinedStaining with COX-2 antibodya
No. of lesions (%)
±++++++
Hyperplasia 22 /33 (66.7) 29 14 (48.3) 14 (48.3) 1 (3.4) 
Dysplasia 21 /33 (63.6) 36 11 (30.6) 20 (55.6) 5 (13.9) 
Papilloma 10 /33 (30.3) 11 6 (54.5) 5 (45.5) 
SCC 11 /33 (33.3) 13 5 (38.5) 6 (46.2) 2 (15.4) 
a

Staining: −, negative; ±,less than 10% of the area weakly positive; +, weakly positive; ++,moderately positive; +++, strongly positive.

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