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Table 4

Stratified analysis of MMP-1 genotypes by gender and smoking status

MMP-1 genotypesCasesControlsUnadjusted OR [95% CI]Adjusted OR [95% CI]
Overall      
 Male 1G/1G, 1G/2G 129 172 Reference Reference 
 2G/2G 120 76 2.11 [1.45–3.06] 2.15 [1.42–3.26]a 
 Female 1G/1G, 1G/2G 117 135 Reference Reference 
 2G/2G 90 68 1.53 [1.02–2.29] 1.34 [0.84–2.15]a 
0–24 pack-years      
 Male 1G/1G, 1G/2G 18 26 Reference Reference 
 2G/2G 14 12 1.69 [0.64–4.43] 1.75 [0.65–4.74]b 
 Female 1G/1G, 1G/2G 22 26 Reference Reference 
 2G/2G 13 12 1.28 [0.49–3.33] 1.23 [0.45–3.33]b 
24.1–40 pack-years      
 Male 1G/1G, 1G/2G 21 37 Reference Reference 
 2G/2G 21 16 2.31 [1.00–5.33] 2.80 [1.14–6.87]b 
 Female 1G/1G, 1G/2G 25 30 Reference Reference 
 2G/2G 19 19 1.20 [0.53–2.73] 1.31 [0.55–3.11]b 
41–61.5 pack-years      
 Male 1G/1G, 1G/2G 39 45 Reference Reference 
 2G/2G 34 20 1.96 [0.98–3.93] 1.99 [0.99–4.02]b 
 Female 1G/1G, 1G/2G 32 32 Reference Reference 
 2G/2G 24 13 1.85 [0.81–4.21] 1.83 [0.80–4.23]b 
≥ 61.5 pack-years      
 Male 1G/1G, 1G/2G 43 58 Reference Reference 
 2G/2G 47 26 2.43 [1.31–4.52] 2.44 [1.31–4.54]b 
 Female 1G/1G, 1G/2G 20 27 Reference Reference 
 2G/2G 18 11 2.21 [0.87–5.63] 2.21 [0.86–5.69]b 
MMP-1 genotypesCasesControlsUnadjusted OR [95% CI]Adjusted OR [95% CI]
Overall      
 Male 1G/1G, 1G/2G 129 172 Reference Reference 
 2G/2G 120 76 2.11 [1.45–3.06] 2.15 [1.42–3.26]a 
 Female 1G/1G, 1G/2G 117 135 Reference Reference 
 2G/2G 90 68 1.53 [1.02–2.29] 1.34 [0.84–2.15]a 
0–24 pack-years      
 Male 1G/1G, 1G/2G 18 26 Reference Reference 
 2G/2G 14 12 1.69 [0.64–4.43] 1.75 [0.65–4.74]b 
 Female 1G/1G, 1G/2G 22 26 Reference Reference 
 2G/2G 13 12 1.28 [0.49–3.33] 1.23 [0.45–3.33]b 
24.1–40 pack-years      
 Male 1G/1G, 1G/2G 21 37 Reference Reference 
 2G/2G 21 16 2.31 [1.00–5.33] 2.80 [1.14–6.87]b 
 Female 1G/1G, 1G/2G 25 30 Reference Reference 
 2G/2G 19 19 1.20 [0.53–2.73] 1.31 [0.55–3.11]b 
41–61.5 pack-years      
 Male 1G/1G, 1G/2G 39 45 Reference Reference 
 2G/2G 34 20 1.96 [0.98–3.93] 1.99 [0.99–4.02]b 
 Female 1G/1G, 1G/2G 32 32 Reference Reference 
 2G/2G 24 13 1.85 [0.81–4.21] 1.83 [0.80–4.23]b 
≥ 61.5 pack-years      
 Male 1G/1G, 1G/2G 43 58 Reference Reference 
 2G/2G 47 26 2.43 [1.31–4.52] 2.44 [1.31–4.54]b 
 Female 1G/1G, 1G/2G 20 27 Reference Reference 
 2G/2G 18 11 2.21 [0.87–5.63] 2.21 [0.86–5.69]b 
a

Adjusted by age and smoking status.

b

Adjusted by age.

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