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Table 3

Stratified analysis of lung cancer risk for the MMP-1 genotypes by smoking status

MMP-1 genotypes	Cases	Controls	Crude OR [95% CI]	Adjusted^a OR [95% CI]
Never smokers
1G/1G, 1G/2G	26	26	Reference	Reference
2G/2G	20	16	1.25 [0.53–2.95]	1.09 [0.31–3.91]
Former smokers
1G/1G, 1G/2G	136	154	Reference	Reference
2G/2G	98	80	1.39 [0.95–2.02]	1.23 [0.81–1.87]
Current smokers
1G/1G, 1G/2G	84	127	Reference	Reference
2G/2G	92	48	2.90 [1.83–4.59]	3.16 [1.87–5.35]
Light^b smokers
1G/1G, 1G/2G	100	140	Reference	Reference
2G/2G	76	65	1.64 [1.07–2.50]	1.40 [0.84–2.32]
Heavy^b smokers
1G/1G, 1G/2G	120	141	Reference	Reference
2G/2G	114	63	2.13 [1.43–3.17]	2.55 [1.61–4.03]

MMP-1 genotypes	Cases	Controls	Crude OR [95% CI]	Adjusted^a OR [95% CI]
Never smokers
1G/1G, 1G/2G	26	26	Reference	Reference
2G/2G	20	16	1.25 [0.53–2.95]	1.09 [0.31–3.91]
Former smokers
1G/1G, 1G/2G	136	154	Reference	Reference
2G/2G	98	80	1.39 [0.95–2.02]	1.23 [0.81–1.87]
Current smokers
1G/1G, 1G/2G	84	127	Reference	Reference
2G/2G	92	48	2.90 [1.83–4.59]	3.16 [1.87–5.35]
Light^b smokers
1G/1G, 1G/2G	100	140	Reference	Reference
2G/2G	76	65	1.64 [1.07–2.50]	1.40 [0.84–2.32]
Heavy^b smokers
1G/1G, 1G/2G	120	141	Reference	Reference
2G/2G	114	63	2.13 [1.43–3.17]	2.55 [1.61–4.03]

Adjusted by age and gender.

Dichotomized at median value of pack-year in the controls. For former and current smokers only.