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Table 3

Stratified analysis of lung cancer risk for the MMP-1 genotypes by smoking status

MMP-1 genotypesCasesControlsCrude OR [95% CI]Adjusteda OR [95% CI]
Never smokers     
1G/1G, 1G/2G 26 26 Reference Reference 
2G/2G 20 16 1.25 [0.53–2.95] 1.09 [0.31–3.91] 
Former smokers     
1G/1G, 1G/2G 136 154 Reference Reference 
2G/2G 98 80 1.39 [0.95–2.02] 1.23 [0.81–1.87] 
Current smokers     
1G/1G, 1G/2G 84 127 Reference Reference 
2G/2G 92 48 2.90 [1.83–4.59] 3.16 [1.87–5.35] 
Lightb smokers     
1G/1G, 1G/2G 100 140 Reference Reference 
2G/2G 76 65 1.64 [1.07–2.50] 1.40 [0.84–2.32] 
Heavyb smokers     
1G/1G, 1G/2G 120 141 Reference Reference 
2G/2G 114 63 2.13 [1.43–3.17] 2.55 [1.61–4.03] 
MMP-1 genotypesCasesControlsCrude OR [95% CI]Adjusteda OR [95% CI]
Never smokers     
1G/1G, 1G/2G 26 26 Reference Reference 
2G/2G 20 16 1.25 [0.53–2.95] 1.09 [0.31–3.91] 
Former smokers     
1G/1G, 1G/2G 136 154 Reference Reference 
2G/2G 98 80 1.39 [0.95–2.02] 1.23 [0.81–1.87] 
Current smokers     
1G/1G, 1G/2G 84 127 Reference Reference 
2G/2G 92 48 2.90 [1.83–4.59] 3.16 [1.87–5.35] 
Lightb smokers     
1G/1G, 1G/2G 100 140 Reference Reference 
2G/2G 76 65 1.64 [1.07–2.50] 1.40 [0.84–2.32] 
Heavyb smokers     
1G/1G, 1G/2G 120 141 Reference Reference 
2G/2G 114 63 2.13 [1.43–3.17] 2.55 [1.61–4.03] 
a

Adjusted by age and gender.

b

Dichotomized at median value of pack-year in the controls. For former and current smokers only.

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