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Table 2

In situ hybridization of adult mouse tissues

Name% idenaNormal adult tissuesbTumors
AdBrHIKi-CKi-MLiLgMPSpStB16HCT
mTEM1 77 − − − − − +++ +++ 
mTEM5 87 − − − − − − +++c +++ 
mTEM7 81 − +++d − − − − − − − − − − − − 
mTEM7R 91 − +e − − +++ +++ − NDf +++ 
mTEM8 96 − − − − − − +++c +++ 
VEGFR N/A +++ ++ +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ 
Name% idenaNormal adult tissuesbTumors
AdBrHIKi-CKi-MLiLgMPSpStB16HCT
mTEM1 77 − − − − − +++ +++ 
mTEM5 87 − − − − − − +++c +++ 
mTEM7 81 − +++d − − − − − − − − − − − − 
mTEM7R 91 − +e − − +++ +++ − NDf +++ 
mTEM8 96 − − − − − − +++c +++ 
VEGFR N/A +++ ++ +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ +++ 
a

The percentage of amino acid identity to homologous human TEMs.

b

−, no endothelial cell staining detected; +, weak positive staining of endothelial cells; ++, moderate staining of endothelial cells; +++, strong staining of endothelial cells. Ad, adrenal gland; B, brain; H, heart; I, intestine; Ki-C, kidney cortex; Ki-M, kidney medulla; Li, liver; Lg, lung; M, skeletal muscle; P, pancreas; Sp, spleen; St, stomach; HCT, HCT116 human colon carcinoma xenograft; B16, B16 mouse melanoma tumor.

c

Endothelial cells were strongly positive; some B16 tumor cells were also weakly positive.

d

Strong staining localized to the Purkinje cells of the cerebellum and some neuronal cells.

e

Weak staining localized primarily to Purkinje cells.

f

ND, not determined.

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