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Table 3

Combined effect of CYP17 and HSD17B1 high-risk alleles on riska of advanced breast cancer among women weighing 170 lbs. or less

No. of high-risk allelesbP (trend)
01234
Subjects weighing ≤170 lbs.       
Controls (n = 1116) 109 319 406 247 35  
Advanced cases (n = 178) 13 44 64 44 13  
RRc 1.00 1.17 1.29 1.48 3.05  
95% CI  (0.61–2.26) (0.68–2.43) (0.76–2.86) (1.29–7.25) 0.02 
No. of high-risk allelesbP (trend)
01234
Subjects weighing ≤170 lbs.       
Controls (n = 1116) 109 319 406 247 35  
Advanced cases (n = 178) 13 44 64 44 13  
RRc 1.00 1.17 1.29 1.48 3.05  
95% CI  (0.61–2.26) (0.68–2.43) (0.76–2.86) (1.29–7.25) 0.02 
a

Age, weight, and ethnicity adjusted.

b

High risk alleles: CYP17, A2;HSD17B1, A.

c

Relative risk for advanced breast cancer.

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