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Table 2

Growth properties of in vivo-derived recurrent variants of A431

Cell typeC225-dependent growth inhibition (% ± SD)aTGF-α-dependent growth inhibition (% ± SD)aDoubling time (h ± SD)bClonogenic survivalc (colony, n ± SD)b
A431 33 ± 5.6 91 ± 5.2 30.2 ± 2.3 186 ± 4.5 
R1 41 ± 10.0 80 ± 3.2 28.7 ± 0.6 189 ± 1.5 
R3 43 ± 5.3 88 ± 7.9 30.6 ± 1.1 111 ± 6.0 
R4 33 ± 11.4 85 ± 7.5 32.4 ± 1.1 176 ± 13.2 
R5 35 ± 8.1 84 ± 9.4 35.4 ± 1.6 58 ± 7.1 
Cell typeC225-dependent growth inhibition (% ± SD)aTGF-α-dependent growth inhibition (% ± SD)aDoubling time (h ± SD)bClonogenic survivalc (colony, n ± SD)b
A431 33 ± 5.6 91 ± 5.2 30.2 ± 2.3 186 ± 4.5 
R1 41 ± 10.0 80 ± 3.2 28.7 ± 0.6 189 ± 1.5 
R3 43 ± 5.3 88 ± 7.9 30.6 ± 1.1 111 ± 6.0 
R4 33 ± 11.4 85 ± 7.5 32.4 ± 1.1 176 ± 13.2 
R5 35 ± 8.1 84 ± 9.4 35.4 ± 1.6 58 ± 7.1 
a

Values represent the average for two independent experiments, each one including triplicates.

b

Calculated from triplicate cultures.

c

The ability of cells to form clonal colonies was analyzed as described previously (58). See “Materials and Methods” for details.

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