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Table 5

Distribution of NAT1*4 and *10 genotypes among slow and rapid NAT2 acetylator genotypes

NAT2 genotypeNAT1 genotypeCases %Controls %Odds ratioa95% CIP
All NAT1*4/*4 69.5 59.2 1.00   
n = 347 cases NAT1*4/*10 28.2 36.7 0.66 0.47–0.94 0.02 
n = 289 controls NAT1*10/*10 2.3 4.2 0.53 0.20–1.40 0.20 
Slow NAT1*4/*4 72.5 70.9 1.00   
n = 229 cases NAT1*4/*10 26.2 26.7 1.04 0.65–1.66 0.86 
n = 172 controls NAT1*10/*10 1.3 2.3 0.75 0.15–3.87 0.73 
Rapid NAT1*4/*4 63.6 41.9 1.00   
n = 118 cases NAT1*4/*10 32.2 51.3 0.39 0.22–0.68 0.001 
n = 117 controls NAT1*10/*10 4.2 6.8 0.42 0.12–1.46 0.17 
NAT2 genotypeNAT1 genotypeCases %Controls %Odds ratioa95% CIP
All NAT1*4/*4 69.5 59.2 1.00   
n = 347 cases NAT1*4/*10 28.2 36.7 0.66 0.47–0.94 0.02 
n = 289 controls NAT1*10/*10 2.3 4.2 0.53 0.20–1.40 0.20 
Slow NAT1*4/*4 72.5 70.9 1.00   
n = 229 cases NAT1*4/*10 26.2 26.7 1.04 0.65–1.66 0.86 
n = 172 controls NAT1*10/*10 1.3 2.3 0.75 0.15–3.87 0.73 
Rapid NAT1*4/*4 63.6 41.9 1.00   
n = 118 cases NAT1*4/*10 32.2 51.3 0.39 0.22–0.68 0.001 
n = 117 controls NAT1*10/*10 4.2 6.8 0.42 0.12–1.46 0.17 
a

Adjusted for age, gender, and extent of smoking.

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