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Table 1

Comparison of structure and some functions of commonly studied p53 mutants

All mutants protected to a similar extent against cisplatin-induced apoptosis.

273 (R to H)248 (R to W or Q)249 (R to S)143 (V to A)175 (R to H)Ref. no.
Frequency of mutation at residue 7% 7% 3% 0.5% 4.5% 88 
Mutation type DNA contact DNA contact Conformational Conformational Conformational 70 
% folded 98 86 85 31 30 102 
Structural changes (NMR)a Local Local Local Extensive NDb 72 
Protection from apoptosisc Low Low ND ND High 41 
Spindle checkpoint disruption ND No ND Yes Yes 73 
273 (R to H)248 (R to W or Q)249 (R to S)143 (V to A)175 (R to H)Ref. no.
Frequency of mutation at residue 7% 7% 3% 0.5% 4.5% 88 
Mutation type DNA contact DNA contact Conformational Conformational Conformational 70 
% folded 98 86 85 31 30 102 
Structural changes (NMR)a Local Local Local Extensive NDb 72 
Protection from apoptosisc Low Low ND ND High 41 
Spindle checkpoint disruption ND No ND Yes Yes 73 
a

NMR, nuclear magnetic resonance. Relative to wild-type p53.

b

ND, not done.

c

Etoposide-induced p53-independent apoptosis.

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