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Table 2

Distribution of individuals and ORs of cancer according to EPHX1 genotypes and predicted mEH activity

GenotypeOral/pharyngeal cancer patients (n = 121)Laryngeal cancer patients (n = 129)Control individuals (n = 172)
n (%)ORa (95% CI)n (%)ORa (95% CI)n (%)
Exon 3 genotypes      
wt3/wt3b 66 (54.5) 1 (Reference) 72 (55.8) 1 (Reference) 64 (37.2) 
wt3/slow 32 (26.5) 0.4 (0.2–0.7) 40 (31.0) 0.4 (0.2–0.7) 77 (44.8) 
slow/slow 23 (19.0) 0.8 (0.4–1.8) 17 (13.2) 0.5 (0.2–1.1) 31 (18.0) 
P for trend  0.17  0.006  
Exon 4 genotypes      
wt4/wt4 80 (66.1) 1 (Reference) 84 (65.1) 1 (Reference) 121 (70.3) 
wt4/rapid 38 (31.4) 1.1 (0.6–2.0)c 41 (31.8) 1.0 (0.6–1.8)c 49 (28.5) 
rapid/rapid 3 (2.5)  4 (3.1)  2 (1.2) 
Predicted mEH activity      
Lowd 42 (34.7) 1 (Reference) 43 (33.3) 1 (Reference) 85 (49.4) 
Intermediatee 55 (45.5) 1.8 (1.0–3.3) 59 (45.7) 1.7 (1.0–3.1) 65 (37.8) 
Highf 24 (19.8) 2.1 (1.0–4.5) 27 (20.9) 2.4 (1.1–5.1) 22 (12.8) 
P for trend  0.03  0.02  
GenotypeOral/pharyngeal cancer patients (n = 121)Laryngeal cancer patients (n = 129)Control individuals (n = 172)
n (%)ORa (95% CI)n (%)ORa (95% CI)n (%)
Exon 3 genotypes      
wt3/wt3b 66 (54.5) 1 (Reference) 72 (55.8) 1 (Reference) 64 (37.2) 
wt3/slow 32 (26.5) 0.4 (0.2–0.7) 40 (31.0) 0.4 (0.2–0.7) 77 (44.8) 
slow/slow 23 (19.0) 0.8 (0.4–1.8) 17 (13.2) 0.5 (0.2–1.1) 31 (18.0) 
P for trend  0.17  0.006  
Exon 4 genotypes      
wt4/wt4 80 (66.1) 1 (Reference) 84 (65.1) 1 (Reference) 121 (70.3) 
wt4/rapid 38 (31.4) 1.1 (0.6–2.0)c 41 (31.8) 1.0 (0.6–1.8)c 49 (28.5) 
rapid/rapid 3 (2.5)  4 (3.1)  2 (1.2) 
Predicted mEH activity      
Lowd 42 (34.7) 1 (Reference) 43 (33.3) 1 (Reference) 85 (49.4) 
Intermediatee 55 (45.5) 1.8 (1.0–3.3) 59 (45.7) 1.7 (1.0–3.1) 65 (37.8) 
Highf 24 (19.8) 2.1 (1.0–4.5) 27 (20.9) 2.4 (1.1–5.1) 22 (12.8) 
P for trend  0.03  0.02  
a

ORs adjusted for sex-, age-, smoking-, and alcohol-related variables. Data on smoking and/or alcohol drinking were missing for six oral/pharynx cancer cases, six larynx cancer cases, and eight control individuals.

b

wt, wild type.

c

Due to small number of rapid/rapidgenotype, ORs were calculated for combined wt4/rapid and rapid/rapidgenotypes.

d

slow/slow and wt4/wt4 genotypes, slow/slow and wt4/rapidgenotypes, wt3/slow and wt4/wt4 genotypes.

e

wt3/wt3 and wt4/wt4 genotypes, wt3/slow and wt4/rapid genotypes.

f

wt3/wt3 and wt4/rapid genotypes, wt3/wt3 and rapid/rapidgenotypes, wt3/slow and rapid/rapidgenotypes.

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