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Table 1

Rat serum concentrations of TAM and its metabolites (OHT, DMT) and the pharmacokinetic parametera

Time (h)TAMOHTDMT
1.5 89.0 ± 45.1 133 ± 18.7 BDL 
3.5 103 ± 36.2 182 ± 33.2 BDL 
52.2 ± 2.5 385 ± 118 BDL 
BDL 128 ± 100 BDL 
18 BDL BDL 50.0 ± 8.55 
24 BDL BDL 1057 ± 431 
48 BDL BDL 2136 ± 1357 
72 BDL BDL 1269 ± 559 
96 BDL BDL 942 ± 249 
AUCb (μg·h/ml) 0.57 2.66 14.9 
Time (h)TAMOHTDMT
1.5 89.0 ± 45.1 133 ± 18.7 BDL 
3.5 103 ± 36.2 182 ± 33.2 BDL 
52.2 ± 2.5 385 ± 118 BDL 
BDL 128 ± 100 BDL 
18 BDL BDL 50.0 ± 8.55 
24 BDL BDL 1057 ± 431 
48 BDL BDL 2136 ± 1357 
72 BDL BDL 1269 ± 559 
96 BDL BDL 942 ± 249 
AUCb (μg·h/ml) 0.57 2.66 14.9 
a

The data points shown are mean SE (n = 5).

b

The AUC were estimated using the Noncompartmental analysis using WinNonlin software (Statistical Consultant, Apex, NC).

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