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Table 2

Incidence and patterns of APC and β-catenin gene mutations and the statusa of β-catenin protein localization in lung lesions induced

No. of samplesIncidence and patterns of mutationsbLocation of β-catenin protein
APCβ-catenin
Adenomas (2/15; 13.3%)  (3/15; 20.0%)   
 3 515 GCT to CGT (Ala to Arg)    Cytoplasm 
 4 679 TGT to TGC (Cys to Cys) Mc   Cell membrane 
 9   32 GAT to GTT (Asp to Val) Nucleus and cytoplasm 
10   34 GGA to GAA (Gly to Glu) Cytoplasm 
12   32 GAT to GTT (Asp to Val) Nucleus and cytoplasm 
Adenocarcinomas (8/20;40.0%)  (5/20; 25.0%)   
 1 292 GAA to AAA (Glu to Lys)    Cytoplasm 
 415 TGC to TGT (Cys to Cys)    
 2 469 GGG to AGG (Gly to Arg)   Nucleus and cytoplasm 
 3 819 GTT to GTC (Val to Val)   Nucleus and cytoplasm 
 1392 AGT to AAT (Ser to Asn)    
 5 1422 GAC to GGC (Asp to Gly) 35 ATC to GTC (lle to Val) Nucleus and cytoplasm 
 6 298 GCT to GCC (Ala to Ala)   Cell membrane 
 8 591 TGG to TGA (Trp to Stop)   Nucleus and cytoplasm 
10   32 GAT to GTT (Asp to Val) Nucleus and cytoplasm 
11   33 TCT to TTT (Ser to Phe) Nucleus and cytoplasm 
13   32 GAT to GTT (Asp to Val) Nucleus and cytoplasm 
16 440 GTT to ATT (Val to lle)   Cytoplasm 
17   41 ACC to ATC (Thr to IIe) Nucleus and cytoplasm 
20 817 ATG to GTG (Met to Val)   Cytoplasm 
No. of samplesIncidence and patterns of mutationsbLocation of β-catenin protein
APCβ-catenin
Adenomas (2/15; 13.3%)  (3/15; 20.0%)   
 3 515 GCT to CGT (Ala to Arg)    Cytoplasm 
 4 679 TGT to TGC (Cys to Cys) Mc   Cell membrane 
 9   32 GAT to GTT (Asp to Val) Nucleus and cytoplasm 
10   34 GGA to GAA (Gly to Glu) Cytoplasm 
12   32 GAT to GTT (Asp to Val) Nucleus and cytoplasm 
Adenocarcinomas (8/20;40.0%)  (5/20; 25.0%)   
 1 292 GAA to AAA (Glu to Lys)    Cytoplasm 
 415 TGC to TGT (Cys to Cys)    
 2 469 GGG to AGG (Gly to Arg)   Nucleus and cytoplasm 
 3 819 GTT to GTC (Val to Val)   Nucleus and cytoplasm 
 1392 AGT to AAT (Ser to Asn)    
 5 1422 GAC to GGC (Asp to Gly) 35 ATC to GTC (lle to Val) Nucleus and cytoplasm 
 6 298 GCT to GCC (Ala to Ala)   Cell membrane 
 8 591 TGG to TGA (Trp to Stop)   Nucleus and cytoplasm 
10   32 GAT to GTT (Asp to Val) Nucleus and cytoplasm 
11   33 TCT to TTT (Ser to Phe) Nucleus and cytoplasm 
13   32 GAT to GTT (Asp to Val) Nucleus and cytoplasm 
16 440 GTT to ATT (Val to lle)   Cytoplasm 
17   41 ACC to ATC (Thr to IIe) Nucleus and cytoplasm 
20 817 ATG to GTG (Met to Val)   Cytoplasm 
a

Staining patterns were divided into three groups: cell membrane, cytoplasm, and nucleus and cytoplasm.

b

codons, base substitutions, and amino acid alterations.

c

Type of mutation: M, missense mutation; S, silent mutation;N, nonsense mutation.

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