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Table 2

Demethylation in different regions of the hMLH1 promoter after 5-aza-2′-deoxycytidine treatment

Cell lineDemethylation extenta in different regions
AbBCD
C1a 4% 23% 40% 40% 
VACO5 22% 17% 19% 24% 
RKO 0% 1% 29% 29% 
29% 32% 33% 29% 
Cell lineDemethylation extenta in different regions
AbBCD
C1a 4% 23% 40% 40% 
VACO5 22% 17% 19% 24% 
RKO 0% 1% 29% 29% 
29% 32% 33% 29% 
a

The extent of demethylation was calculated by averaging the percentage of meth-ylation of all CpG sites in the region before 5-aza-2′-deoxycytidine treatment subtracted by the average percentage of methylation after treatment. The concentrations of 5-aza-2′-deoxycytidine used to treat cell lines C1a, VACO5, RKO, and C were 5, 15, 10, and 5 μm, respectively.

b

Regions A, B, C, and D are the same as in Table 1.

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