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Table 1

MSI, hMLH1 mutations, expression, and methylation status in human colorectal cancer cell lines

Cell lineMSIhMLH1 mutationhMLH1 expressionMethylation in different regions (%)a
AbBcCdDe
SW1116 − wild typef 62 
HCT8 −  57 
Colo201 − wild typef 60 
Colo320 − wild typef 55 
RW2982 −  61 
RW7213 −  57 
H498 −  59 
VACO411 −  64 
VACO10P −  60 
CaCo2 − wild typef 67 
SW1463 −  40 
HRT18 −  54 
HT29 − wild typef 35 37 
SW620 − wild typef 24 10 
LS123 −  36 24 
LS174T exon 4, codon 117, ACG to ATG, Thr to Metg 45 11 
HCT116 exon 9, codon 252, TCA to TAA, Ser to Stoph,i 62 
C1a exon 5, codon 129, AGT to GGT, Ser to Glyg − 95 82 100 89 
SW48 wild typef,j − 98 96 100 93 
VACO5 wild typef,i,j − 98 96 100 100 
VACO6 wild typeh,i − 95 80 100 38 
RKO wild typei − 79 82 94 76 
wild typeg − 90 85 98 79 
Lovok wild typef 60 
Cell lineMSIhMLH1 mutationhMLH1 expressionMethylation in different regions (%)a
AbBcCdDe
SW1116 − wild typef 62 
HCT8 −  57 
Colo201 − wild typef 60 
Colo320 − wild typef 55 
RW2982 −  61 
RW7213 −  57 
H498 −  59 
VACO411 −  64 
VACO10P −  60 
CaCo2 − wild typef 67 
SW1463 −  40 
HRT18 −  54 
HT29 − wild typef 35 37 
SW620 − wild typef 24 10 
LS123 −  36 24 
LS174T exon 4, codon 117, ACG to ATG, Thr to Metg 45 11 
HCT116 exon 9, codon 252, TCA to TAA, Ser to Stoph,i 62 
C1a exon 5, codon 129, AGT to GGT, Ser to Glyg − 95 82 100 89 
SW48 wild typef,j − 98 96 100 93 
VACO5 wild typef,i,j − 98 96 100 100 
VACO6 wild typeh,i − 95 80 100 38 
RKO wild typei − 79 82 94 76 
wild typeg − 90 85 98 79 
Lovok wild typef 60 
a

The average of methylation percentage of all CpG sites in each region.

b

From −711 to −577, containing 23 CpG sites.

c

From −552 to −266, containing 19 CpG sites.

d

From −248 to −178, containing eight CpG sites.

e

From −109 to +15, containing seven CpG sites.

f

Ref. 17.

g

Determined in this study.

h

Ref. 6.

i

Ref. 14.

j

Ref. 8.

k

Lovo shows the expression of truncated RNA (exons 4–8 deletion) of hMSH2 gene.

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