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Table 1

Frequencies of polymorphisms in CYPIA1, GSTP1, GSTM1, and GSTT1 genes in controls and patients with Barrett’s esophagus, adenocarcinoma, and squamous cell carcinoma of the esophagusa

Patients
GeneVariantControls (n = 247)Barrett’s esophagus (n = 98)Adenocarcinoma (n = 21)Squamous cell carcinoma (n = 13)
CYPIA1 (exon 7) Ile/Ile 207 (84) 78 (80) 18 (86) 8 (61) 
 Ile/Val 37 (15) 16 (16) 3 (14) 5 (39) 
 Val/Val 3 (1) 4 (4) 0 (0) 0 (0) 
CYPIA1 (3′ flanking region) T/T 207 (84) 85 (87) 14 (67) 8 (61) 
 T/C 37 (15) 12 (12) 7 (33) 5 (39) 
 C/C 3 (1) 1 (1) 0 (0) 0 (0) 
GSTP1a-1a Ile/Ile 146 (59) 29 (30) 5 (24) 5 (39) 
GSTP1a-1b Ile/Val 89 (36) 58 (59)b 15 (71)c 6 (46) 
GSTP1b-1b Val/Val 12 (5) 11 (11) 1 (5) 2 (15) 
GSTM1 Deletion 128 (52) 43 (44) 12 (57) 5 (39) 
GSTT1 Deletion 49 (20) 24 (25) 4 (19) 2 (15) 
Patients
GeneVariantControls (n = 247)Barrett’s esophagus (n = 98)Adenocarcinoma (n = 21)Squamous cell carcinoma (n = 13)
CYPIA1 (exon 7) Ile/Ile 207 (84) 78 (80) 18 (86) 8 (61) 
 Ile/Val 37 (15) 16 (16) 3 (14) 5 (39) 
 Val/Val 3 (1) 4 (4) 0 (0) 0 (0) 
CYPIA1 (3′ flanking region) T/T 207 (84) 85 (87) 14 (67) 8 (61) 
 T/C 37 (15) 12 (12) 7 (33) 5 (39) 
 C/C 3 (1) 1 (1) 0 (0) 0 (0) 
GSTP1a-1a Ile/Ile 146 (59) 29 (30) 5 (24) 5 (39) 
GSTP1a-1b Ile/Val 89 (36) 58 (59)b 15 (71)c 6 (46) 
GSTP1b-1b Val/Val 12 (5) 11 (11) 1 (5) 2 (15) 
GSTM1 Deletion 128 (52) 43 (44) 12 (57) 5 (39) 
GSTT1 Deletion 49 (20) 24 (25) 4 (19) 2 (15) 
a

Genetic polymorphisms were detected as described in “Materials and Methods.” Percentages are given in parentheses. The statistical significance of differences between patient and control group was assessed in 2 × 2 (GSTM1 and GSTT1) or 2 × 3 (GSTP1 and CYPIA1) contingency tables with χ2 analyses. n, number of patients or controls.

b

P < 0.0001.

c

P = 0.005.

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