Frequencies of polymorphisms in CYPIA1, GSTP1, GSTM1, and GSTT1 genes in controls and patients with Barrett’s esophagus, adenocarcinoma, and squamous cell carcinoma of the esophagusa
| . | . | . | Patients . | . | . | ||
|---|---|---|---|---|---|---|---|
| Gene . | Variant . | Controls (n = 247) . | Barrett’s esophagus (n = 98) . | Adenocarcinoma (n = 21) . | Squamous cell carcinoma (n = 13) . | ||
| CYPIA1 (exon 7) | Ile/Ile | 207 (84) | 78 (80) | 18 (86) | 8 (61) | ||
| Ile/Val | 37 (15) | 16 (16) | 3 (14) | 5 (39) | |||
| Val/Val | 3 (1) | 4 (4) | 0 (0) | 0 (0) | |||
| CYPIA1 (3′ flanking region) | T/T | 207 (84) | 85 (87) | 14 (67) | 8 (61) | ||
| T/C | 37 (15) | 12 (12) | 7 (33) | 5 (39) | |||
| C/C | 3 (1) | 1 (1) | 0 (0) | 0 (0) | |||
| GSTP1a-1a | Ile/Ile | 146 (59) | 29 (30) | 5 (24) | 5 (39) | ||
| GSTP1a-1b | Ile/Val | 89 (36) | 58 (59)b | 15 (71)c | 6 (46) | ||
| GSTP1b-1b | Val/Val | 12 (5) | 11 (11) | 1 (5) | 2 (15) | ||
| GSTM1 | Deletion | 128 (52) | 43 (44) | 12 (57) | 5 (39) | ||
| GSTT1 | Deletion | 49 (20) | 24 (25) | 4 (19) | 2 (15) | ||
| . | . | . | Patients . | . | . | ||
|---|---|---|---|---|---|---|---|
| Gene . | Variant . | Controls (n = 247) . | Barrett’s esophagus (n = 98) . | Adenocarcinoma (n = 21) . | Squamous cell carcinoma (n = 13) . | ||
| CYPIA1 (exon 7) | Ile/Ile | 207 (84) | 78 (80) | 18 (86) | 8 (61) | ||
| Ile/Val | 37 (15) | 16 (16) | 3 (14) | 5 (39) | |||
| Val/Val | 3 (1) | 4 (4) | 0 (0) | 0 (0) | |||
| CYPIA1 (3′ flanking region) | T/T | 207 (84) | 85 (87) | 14 (67) | 8 (61) | ||
| T/C | 37 (15) | 12 (12) | 7 (33) | 5 (39) | |||
| C/C | 3 (1) | 1 (1) | 0 (0) | 0 (0) | |||
| GSTP1a-1a | Ile/Ile | 146 (59) | 29 (30) | 5 (24) | 5 (39) | ||
| GSTP1a-1b | Ile/Val | 89 (36) | 58 (59)b | 15 (71)c | 6 (46) | ||
| GSTP1b-1b | Val/Val | 12 (5) | 11 (11) | 1 (5) | 2 (15) | ||
| GSTM1 | Deletion | 128 (52) | 43 (44) | 12 (57) | 5 (39) | ||
| GSTT1 | Deletion | 49 (20) | 24 (25) | 4 (19) | 2 (15) | ||
Genetic polymorphisms were detected as described in “Materials and Methods.” Percentages are given in parentheses. The statistical significance of differences between patient and control group was assessed in 2 × 2 (GSTM1 and GSTT1) or 2 × 3 (GSTP1 and CYPIA1) contingency tables with χ2 analyses. n, number of patients or controls.
P < 0.0001.
P = 0.005.