The association between the germline variant rs61757955 and genomic and histological variables
| Variable . | Mean or Percentage (Wild Type) . | Mean or Percentage (Mutant) . | P-value . |
|---|---|---|---|
| CIC Mutated | 15.9% | 38.1% | 0.017 |
| 1p/19q Co-deletion | 25.2% | 47.6% | 0.038 |
| Oligodendroglioma | 33.7% | 42.9% | 0.475 |
| Total Somatic Mutation Count | 30.9 | 30.0 | 0.766 |
| Percent Aneuploidy | 15.1% | 11.7% | 0.524 |
| Astrocytoma | 38.1% | 42.9% | 0.651 |
| Grade 3 | 53.0% | 42.9% | 0.497 |
| IDH Mutated | 78.1% | 85.7% | 0.583 |
| 1p/19q Co-deletion | 25.2% | 47.6% | 0.038 |
| MGMT Promoter Methylation | 77.8% | 81.0% | 1.000 |
| Chr 7 Gain/Chr 10 Loss | 13.0% | 9.5% | 1.000 |
| Expression of GRB2 (FPKM) | 45.7 | 44.4 | 0.636 |
| Variable . | Mean or Percentage (Wild Type) . | Mean or Percentage (Mutant) . | P-value . |
|---|---|---|---|
| CIC Mutated | 15.9% | 38.1% | 0.017 |
| 1p/19q Co-deletion | 25.2% | 47.6% | 0.038 |
| Oligodendroglioma | 33.7% | 42.9% | 0.475 |
| Total Somatic Mutation Count | 30.9 | 30.0 | 0.766 |
| Percent Aneuploidy | 15.1% | 11.7% | 0.524 |
| Astrocytoma | 38.1% | 42.9% | 0.651 |
| Grade 3 | 53.0% | 42.9% | 0.497 |
| IDH Mutated | 78.1% | 85.7% | 0.583 |
| 1p/19q Co-deletion | 25.2% | 47.6% | 0.038 |
| MGMT Promoter Methylation | 77.8% | 81.0% | 1.000 |
| Chr 7 Gain/Chr 10 Loss | 13.0% | 9.5% | 1.000 |
| Expression of GRB2 (FPKM) | 45.7 | 44.4 | 0.636 |
NOTE: Patients were divided based on whether or not they had the germline variant rs61757955. Patients with the germline variant rs61757955 were more likely (p < 0.05) to have CIC-mutated gliomas and the 1p/19q codeletion (bold).