List of variables that are known to be associated with differences in survival in lower grade glioma patients
| Covariate . | Median (min–max) or number of patients . | |
|---|---|---|
| Age | 41 (14–87) | |
| Gender | Female | 250 |
| Male | 200 | |
| Somatic mutation count | 50 (0–12255) | |
| Percent aneuploidy | 11% (5.2E-4%–95%) | |
| log(TERT Expression) | 1.0 (0.0–9.1) FPKM | |
| Principal component 1 (PC1) | 0.043 (−0.091–0.064) | |
| Principal component 2 (PC2) | −0.017 (−0.23–0.17) | |
| Principal component 3 (PC3) | −0.53 (1.34E-4–0.33) | |
| Histologic type | Astroctyoma | 172 |
| Oligoastrocytoma | 113 | |
| Oligodendroglioma | 165 | |
| Tumor location | Frontal lobe | 265 |
| Temporal lobe | 125 | |
| Parietal lobe | 42 | |
| Other | 18 | |
| Grade | G2 | 212 |
| G3 | 237 | |
| Cannot be assessed | 1 | |
| Treatment site | Henry Fords Hospital | 82 |
| Case Western St. Joseph Hospital | 90 | |
| Other | 278 | |
| IDH Mutant | Wild type | 83 |
| Mutant | 367 | |
| 1p/19q Codeletion | Absent | 303 |
| Present | 147 | |
| MGMT Promoter methylation | Unmethylated | 80 |
| Methylated | 370 | |
| Chr 7 gain/Chr 10 loss | Absent | 399 |
| Present | 51 | |
| TP53 Mutant | Absent | 232 |
| Present | 218 | |
| Covariate . | Median (min–max) or number of patients . | |
|---|---|---|
| Age | 41 (14–87) | |
| Gender | Female | 250 |
| Male | 200 | |
| Somatic mutation count | 50 (0–12255) | |
| Percent aneuploidy | 11% (5.2E-4%–95%) | |
| log(TERT Expression) | 1.0 (0.0–9.1) FPKM | |
| Principal component 1 (PC1) | 0.043 (−0.091–0.064) | |
| Principal component 2 (PC2) | −0.017 (−0.23–0.17) | |
| Principal component 3 (PC3) | −0.53 (1.34E-4–0.33) | |
| Histologic type | Astroctyoma | 172 |
| Oligoastrocytoma | 113 | |
| Oligodendroglioma | 165 | |
| Tumor location | Frontal lobe | 265 |
| Temporal lobe | 125 | |
| Parietal lobe | 42 | |
| Other | 18 | |
| Grade | G2 | 212 |
| G3 | 237 | |
| Cannot be assessed | 1 | |
| Treatment site | Henry Fords Hospital | 82 |
| Case Western St. Joseph Hospital | 90 | |
| Other | 278 | |
| IDH Mutant | Wild type | 83 |
| Mutant | 367 | |
| 1p/19q Codeletion | Absent | 303 |
| Present | 147 | |
| MGMT Promoter methylation | Unmethylated | 80 |
| Methylated | 370 | |
| Chr 7 gain/Chr 10 loss | Absent | 399 |
| Present | 51 | |
| TP53 Mutant | Absent | 232 |
| Present | 218 | |
NOTE: Eleven variables (bolded) were selected by Lasso for inclusion in the survival model. We used these 11 variables as covariates in our Cox regression model when testing each germline variant.