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Table 5.

Incidence of treatment-related adverse events

ToxicityCycle 1 and crossover cycle 2 ABI-007 (n = 15)
Cycle 1 and crossover cycle 2 Taxol (n = 16)
Cycle 3 ABI-007 and beyond (n = 13)
Grade 1-2
Grade 3
Grade 4
Grade 1-2
Grade 3
Grade 4
Grade 1-2
Grade 3
Grade 4
No%No%No%No%No%No%No%No%No%
Body as a whole                   
    Alopecia 33     37.5           
    Anorexia/weight loss     12.5         
    Arthralgia/Pain 13     12.5     23     
    Fatigue       25     31     
    Headache 13             
    Hypersensitivity reaction                 
Blood/bone marrow changes                   
    Anemia       15 15   
    Thrombocytopenia               15   
    Leukopenia 25 12.5     15 
    Neutropenia   13 13 19   15 23 
    Lymphopenia   20   12.5       
    Febrile neutropenia               
Digestive system                   
    Mucositis 13               
    Nausea/vomiting 33     12.5     38     
    Diarrhea     12.5       
    Dyspepsia       12.5           
    Dysgeusia 13         23     
    Flatulence/adominal distention               
Pulmonary/cardiovascular system                   
    Dyspnea               
Nervous/muscular system                   
    Dizziness     12.5     15     
    Neuropathy:sensory 13     12.5     15   
    Muscle weakness               
Metabolic/laboratory abnormalities                   
    Increased PTT     12.5       
    Hypermagnesemia               15   
    Hypocalcemia             15   
    Hypophosphatemia                 
    Hypokalemia                 
ToxicityCycle 1 and crossover cycle 2 ABI-007 (n = 15)
Cycle 1 and crossover cycle 2 Taxol (n = 16)
Cycle 3 ABI-007 and beyond (n = 13)
Grade 1-2
Grade 3
Grade 4
Grade 1-2
Grade 3
Grade 4
Grade 1-2
Grade 3
Grade 4
No%No%No%No%No%No%No%No%No%
Body as a whole                   
    Alopecia 33     37.5           
    Anorexia/weight loss     12.5         
    Arthralgia/Pain 13     12.5     23     
    Fatigue       25     31     
    Headache 13             
    Hypersensitivity reaction                 
Blood/bone marrow changes                   
    Anemia       15 15   
    Thrombocytopenia               15   
    Leukopenia 25 12.5     15 
    Neutropenia   13 13 19   15 23 
    Lymphopenia   20   12.5       
    Febrile neutropenia               
Digestive system                   
    Mucositis 13               
    Nausea/vomiting 33     12.5     38     
    Diarrhea     12.5       
    Dyspepsia       12.5           
    Dysgeusia 13         23     
    Flatulence/adominal distention               
Pulmonary/cardiovascular system                   
    Dyspnea               
Nervous/muscular system                   
    Dizziness     12.5     15     
    Neuropathy:sensory 13     12.5     15   
    Muscle weakness               
Metabolic/laboratory abnormalities                   
    Increased PTT     12.5       
    Hypermagnesemia               15   
    Hypocalcemia             15   
    Hypophosphatemia                 
    Hypokalemia                 
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