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Table 4.

Comparison of unbound paclitaxel pharmacokinetic variables for first cycles of nab-paclitaxel and sb-paclitaxel (n = 14)

nab-paclitaxel (260 mg/m2)
sb-paclitaxel (175 mg/m2)
P
MeanRange%CVMeanRange%CV
Cmax (ng/mL) 1,283.7 419.3-2,401.9 41.5% 121.8 65.9-198.3 32.5% <0.000001 
Cmax/dose (ng/mL per mg/m2) 4.9 1.6-9.2 41.5% 0.7 0.4-1.1 32.5% <0.000005 
AUCINF (h*ng/mL) 1,158.8 636.6-1,759.4 29.1% 409.9 207.3-649.3 35.0% <0.000005 
AUCINF_Dose (h*ng/mL per mg/m2) 4.5 2.5-6.9 27.4% 2.3 1.2-3.7 35.0% 0.0002 
AUC 0-4.5 (h*ng/mL) 969.2 355.0-1,661.9 32.9%    0.0002 
AUC 0-7 (h*ng/mL)    361.1 193.2-589.0 32.3%  
nab-paclitaxel (260 mg/m2)
sb-paclitaxel (175 mg/m2)
P
MeanRange%CVMeanRange%CV
Cmax (ng/mL) 1,283.7 419.3-2,401.9 41.5% 121.8 65.9-198.3 32.5% <0.000001 
Cmax/dose (ng/mL per mg/m2) 4.9 1.6-9.2 41.5% 0.7 0.4-1.1 32.5% <0.000005 
AUCINF (h*ng/mL) 1,158.8 636.6-1,759.4 29.1% 409.9 207.3-649.3 35.0% <0.000005 
AUCINF_Dose (h*ng/mL per mg/m2) 4.5 2.5-6.9 27.4% 2.3 1.2-3.7 35.0% 0.0002 
AUC 0-4.5 (h*ng/mL) 969.2 355.0-1,661.9 32.9%    0.0002 
AUC 0-7 (h*ng/mL)    361.1 193.2-589.0 32.3%  
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