Comparison of unbound paclitaxel pharmacokinetic variables for first cycles of nab-paclitaxel and sb-paclitaxel (n = 14)
| . | nab-paclitaxel (260 mg/m2) . | . | . | sb-paclitaxel (175 mg/m2) . | . | . | P . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Mean . | Range . | %CV . | Mean . | Range . | %CV . | . | ||||
| Cmax (ng/mL) | 1,283.7 | 419.3-2,401.9 | 41.5% | 121.8 | 65.9-198.3 | 32.5% | <0.000001 | ||||
| Cmax/dose (ng/mL per mg/m2) | 4.9 | 1.6-9.2 | 41.5% | 0.7 | 0.4-1.1 | 32.5% | <0.000005 | ||||
| AUCINF (h*ng/mL) | 1,158.8 | 636.6-1,759.4 | 29.1% | 409.9 | 207.3-649.3 | 35.0% | <0.000005 | ||||
| AUCINF_Dose (h*ng/mL per mg/m2) | 4.5 | 2.5-6.9 | 27.4% | 2.3 | 1.2-3.7 | 35.0% | 0.0002 | ||||
| AUC 0-4.5 (h*ng/mL) | 969.2 | 355.0-1,661.9 | 32.9% | 0.0002 | |||||||
| AUC 0-7 (h*ng/mL) | 361.1 | 193.2-589.0 | 32.3% | ||||||||
| . | nab-paclitaxel (260 mg/m2) . | . | . | sb-paclitaxel (175 mg/m2) . | . | . | P . | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| . | Mean . | Range . | %CV . | Mean . | Range . | %CV . | . | ||||
| Cmax (ng/mL) | 1,283.7 | 419.3-2,401.9 | 41.5% | 121.8 | 65.9-198.3 | 32.5% | <0.000001 | ||||
| Cmax/dose (ng/mL per mg/m2) | 4.9 | 1.6-9.2 | 41.5% | 0.7 | 0.4-1.1 | 32.5% | <0.000005 | ||||
| AUCINF (h*ng/mL) | 1,158.8 | 636.6-1,759.4 | 29.1% | 409.9 | 207.3-649.3 | 35.0% | <0.000005 | ||||
| AUCINF_Dose (h*ng/mL per mg/m2) | 4.5 | 2.5-6.9 | 27.4% | 2.3 | 1.2-3.7 | 35.0% | 0.0002 | ||||
| AUC 0-4.5 (h*ng/mL) | 969.2 | 355.0-1,661.9 | 32.9% | 0.0002 | |||||||
| AUC 0-7 (h*ng/mL) | 361.1 | 193.2-589.0 | 32.3% | ||||||||