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Table 3.

Comparison of total drug pharmacokinetic variables for first cycles of nab-paclitaxel and sb-paclitaxel (n = 14)

nab-paclitaxel
sb-paclitaxel
P
(260 mg/m2)
(175 mg/m2)
MeanRange%CVMeanRange%CV
T1/2 (h) 20.0 15.5-31.2 21.3% 20.9 15.7-34.0 21.4% 0.53 
Cmax (ng/mL) 19,556.4 10,613.1-34,201.4 36.2% 5,128.0 3,136.0-8,832.3 32.7% <0.00001 
Cmax/dose (ng/mL per mg/m2) 75.2 40.8-131.5 36.2% 29.3 17.9-50.5 32.7% <0.00001 
AUCINF (h*ng/mL) 20,324.5 15,539.2-29,447.9 19.5% 20,821.1 12,973.4-30,622.2 25.9% 0.72 
AUCINF_Dose (h*ng/mL per mg/m2) 78.2 59.8-175.0 19.5% 119.0 74.1-175.0 25.9% 0.0001 
Vz_obs (L/m2) 375.4 269.6-571.1 21.9% 270.8 151.0-457.2 61.4% 0.003 
Cl_obs (L/h/m2) 13.2 8.8-16.7 17.9% 8.9 5.7-13.5 25.7% 0.00002 
nab-paclitaxel
sb-paclitaxel
P
(260 mg/m2)
(175 mg/m2)
MeanRange%CVMeanRange%CV
T1/2 (h) 20.0 15.5-31.2 21.3% 20.9 15.7-34.0 21.4% 0.53 
Cmax (ng/mL) 19,556.4 10,613.1-34,201.4 36.2% 5,128.0 3,136.0-8,832.3 32.7% <0.00001 
Cmax/dose (ng/mL per mg/m2) 75.2 40.8-131.5 36.2% 29.3 17.9-50.5 32.7% <0.00001 
AUCINF (h*ng/mL) 20,324.5 15,539.2-29,447.9 19.5% 20,821.1 12,973.4-30,622.2 25.9% 0.72 
AUCINF_Dose (h*ng/mL per mg/m2) 78.2 59.8-175.0 19.5% 119.0 74.1-175.0 25.9% 0.0001 
Vz_obs (L/m2) 375.4 269.6-571.1 21.9% 270.8 151.0-457.2 61.4% 0.003 
Cl_obs (L/h/m2) 13.2 8.8-16.7 17.9% 8.9 5.7-13.5 25.7% 0.00002 

Abbreviation: %CV, % coefficient of variation.

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