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Table 2.

Comparison of nab-paclitaxel cycles 1 and 2 pharmacokinetics (n = 12)

Mean ratio (cycle 2/cycle 1)95% confidence intervalP
T1/2 (h) 0.93 0.76-1.10 0.28 
Cmax (ng/mL) 1.17 0.80-1.53 0.57 
AUCINF (h*ng/mL) 1.08 0.84-1.32 0.55 
Vz_obs (L/m2) 0.96 0.68-1.25 0.70 
Cl_obs (L/h/m2) 1.02 0.81-1.23 0.95 
Mean ratio (cycle 2/cycle 1)95% confidence intervalP
T1/2 (h) 0.93 0.76-1.10 0.28 
Cmax (ng/mL) 1.17 0.80-1.53 0.57 
AUCINF (h*ng/mL) 1.08 0.84-1.32 0.55 
Vz_obs (L/m2) 0.96 0.68-1.25 0.70 
Cl_obs (L/h/m2) 1.02 0.81-1.23 0.95 

NOTE: Cycle 1, initial cycle of nab-paclitaxel—either C1 or crossover C2. Cycle 2, third overall treatment cycle.

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