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Table 1.

Baseline characteristics of patients enrolled (13 patients)

CharacteristicNumber
Age, median (range) 56 (42-81) 
Women 11 
Histology  
    Adenocarcinoma 11 
    NSCLC 
Smoking history  
    Never smokers 
    ≤15 pack-y 
    >15 pack-y 
Time from diagnosis of metastatic disease (mo)  
    Median (range) 20 (8-91) 
Previous treatment  
    Erlotinib 
    Gefitinib 
Time on erlotinib or gefitinib (mo)  
    Median (range) 16 (8-79) 
EGFR  
    L858R* 
    Exon 19 deletion 
    Not available 
CharacteristicNumber
Age, median (range) 56 (42-81) 
Women 11 
Histology  
    Adenocarcinoma 11 
    NSCLC 
Smoking history  
    Never smokers 
    ≤15 pack-y 
    >15 pack-y 
Time from diagnosis of metastatic disease (mo)  
    Median (range) 20 (8-91) 
Previous treatment  
    Erlotinib 
    Gefitinib 
Time on erlotinib or gefitinib (mo)  
    Median (range) 16 (8-79) 
EGFR  
    L858R* 
    Exon 19 deletion 
    Not available 
*

On biopsy material obtained after treatment with gefitinib, one patient had both L858R and T790M.

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