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Table 3.

Relationship between use of statins and breast cancer risk by solubility and for the most commonly used statin medications

Controls (n = 877)Ductal cases (n = 891)Lobular cases (n = 1,036)
N (%)N (%)OR (95% CI)N (%)OR (95% CI)
Never use 674 (76.9) 664 (74.8) 1.00 (reference) 782 (75.6) 1.00 (reference) 
Hydrophilic statins 
Current use 13 (1.5) 18 (2.0) 1.56 (0.75–3.24) 21 (2.0) 1.65 (0.81–3.38) 
Lipophilic statins 
Current use 157 (17.9) 166 (18.7) 1.13 (0.88–1.45) 196 (18.9) 1.21 (0.95–1.54) 
 6 months–<5 years 84 (9.6) 76 (8.6) 0.95 (0.68–1.33) 104 (10.1) 1.17 (0.86–1.61) 
 5 yrs–<10 yrs 44 (5) 45 (5.1) 1.09 (0.70–1.69) 44 (4.3) 0.96 (0.62–1.50) 
 ≥10 years 28 (3.2) 43 (4.8) 1.74 (1.05–2.86) 45 (4.4) 1.68 (1.02–2.76) 
Ptrend   P = 0.119  P = 0.094 
Atorvastatin 
Current use 77 (8.8) 93 (10.5) 1.34 (0.96–1.85) 98 (9.5) 1.25 (0.91–1.74) 
 6 months–<5 years 37 (4.2) 47 (5.3) 1.39 (0.88–2.17) 56 (5.4) 1.46 (0.94–2.25) 
 5 yrs–<10 yrs 28 (3.2) 26 (2.9) 1.01 (0.58–1.77) 24 (2.3) 0.85 (0.48–1.51) 
 ≥10 years 12 (1.4) 20 (2.3) 1.97 (0.94–4.11) 18 (1.7) 1.55 (0.73–3.30) 
Ptrend   P = 0.048  P = 0.254 
Simvastatin 
Current use 50 (5.7) 49 (5.5) 0.97 (0.64–1.48) 57 (5.5) 1.05 (0.70–1.57) 
 6 months–<5 years 30 (3.4) 29 (3.3) 0.93 (0.54–1.58) 35 (3.4) 1.03 (0.62–1.72) 
 5 yrs–<10 yrs 14 (1.6) 12 (1.4) 0.94 (0.42–2.07) 13 (1.3) 0.90 (0.41–1.96) 
 ≥10 years 6 (0.7) 8 (0.9) 1.30 (0.44–3.85) 9 (0.9) 1.49 (0.52–4.28) 
Ptrend   P = 0.729  P = 0.681 
Controls (n = 877)Ductal cases (n = 891)Lobular cases (n = 1,036)
N (%)N (%)OR (95% CI)N (%)OR (95% CI)
Never use 674 (76.9) 664 (74.8) 1.00 (reference) 782 (75.6) 1.00 (reference) 
Hydrophilic statins 
Current use 13 (1.5) 18 (2.0) 1.56 (0.75–3.24) 21 (2.0) 1.65 (0.81–3.38) 
Lipophilic statins 
Current use 157 (17.9) 166 (18.7) 1.13 (0.88–1.45) 196 (18.9) 1.21 (0.95–1.54) 
 6 months–<5 years 84 (9.6) 76 (8.6) 0.95 (0.68–1.33) 104 (10.1) 1.17 (0.86–1.61) 
 5 yrs–<10 yrs 44 (5) 45 (5.1) 1.09 (0.70–1.69) 44 (4.3) 0.96 (0.62–1.50) 
 ≥10 years 28 (3.2) 43 (4.8) 1.74 (1.05–2.86) 45 (4.4) 1.68 (1.02–2.76) 
Ptrend   P = 0.119  P = 0.094 
Atorvastatin 
Current use 77 (8.8) 93 (10.5) 1.34 (0.96–1.85) 98 (9.5) 1.25 (0.91–1.74) 
 6 months–<5 years 37 (4.2) 47 (5.3) 1.39 (0.88–2.17) 56 (5.4) 1.46 (0.94–2.25) 
 5 yrs–<10 yrs 28 (3.2) 26 (2.9) 1.01 (0.58–1.77) 24 (2.3) 0.85 (0.48–1.51) 
 ≥10 years 12 (1.4) 20 (2.3) 1.97 (0.94–4.11) 18 (1.7) 1.55 (0.73–3.30) 
Ptrend   P = 0.048  P = 0.254 
Simvastatin 
Current use 50 (5.7) 49 (5.5) 0.97 (0.64–1.48) 57 (5.5) 1.05 (0.70–1.57) 
 6 months–<5 years 30 (3.4) 29 (3.3) 0.93 (0.54–1.58) 35 (3.4) 1.03 (0.62–1.72) 
 5 yrs–<10 yrs 14 (1.6) 12 (1.4) 0.94 (0.42–2.07) 13 (1.3) 0.90 (0.41–1.96) 
 ≥10 years 6 (0.7) 8 (0.9) 1.30 (0.44–3.85) 9 (0.9) 1.49 (0.52–4.28) 
Ptrend   P = 0.729  P = 0.681 

NOTE: OR adjusted for reference year, reference age, county of residence, and hormone therapy use. Bold values signify statistically significant estimates (P value <0.05).

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