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Table 3.

Association of dietary factors with risk of CML in the NIH-AARP Diet and Health Study, 1995 to 2006

Multivariable modela
No. of casesNo. of person-yearsHR95% CI
Red meat (g/day)b 
 <27.3 33 1,228,647 1.00 Ref. 
 27.3–<51.3 42 1,119,335 1.20 0.74–1.95 
 51.3–<87.6 50 1,108,332 1.36 0.85–2.17 
 ≥87.6 53 1,101,246 1.33 0.83–2.13 
P for trend   0.25  
Total meat (g/day) 
 <67.9 39 1,116,426 1.00 Ref. 
 67.9–<106.9 47 1,112,529 1.12 0.72–1.74 
 106.9–<161.3 48 1,114,098 1.23 0.80–1.90 
 ≥161.3 44 1,114,509 1.11 0.71–1.73 
P for trend   0.65  
White meat (g/day)b 
 <25.8 39 1,101,159 1.00 Ref. 
 25.8–<46.0 50 1,110,974 0.82 0.53–1.26 
 46.0–<77.8 48 1,118,285 1.15 0.76–1.72 
 ≥77.8 41 1,127,144 0.94 0.61–1.46 
P for trend   0.89  
Processed meat (g/day)b 
 <2.8 41 1,127,532 1.00 Ref. 
 2.8–<6.6 38 1,123,322 0.80 0.50–1.26 
 6.6–<15.4 52 1,111,307 1.01 0.65–1.59 
 ≥15.4 47 1,095,399 0.62 0.36–1.07 
P for trend   0.14  
Fish (g/day) 
 <4.2 55 1,110,495 1.00 Ref. 
 4.2–<7.9 51 1,113,299 0.91 0.62–1.35 
 7.9–<14.2 34 1,113,995 0.63 0.41–0.98 
 ≥14.2 38 1,119,773 0.73 0.48–1.11 
P for trend   0.11  
Total fruit (cup equivalents/day) 
 <0.97 37 1,093,153 1.00 Ref. 
 0.97–<1.69 50 1,128,735 1.45 0.93–2.25 
 1.69–<2.65 55 1,110,765 1.68 1.09–2.60 
 ≥2.65 96 1,124,909 1.12 0.69–1.81 
P for trend   0.84  
Total vegetables (cup equivalents/day) 
 <1.14 30 778,204 1.00 Ref. 
 1.14–<1.71 53 1,391,457 1.12 0.70–1.80 
 1.71–<2.48 56 1,330,487 1.28 0.80–2.04 
 ≥2.48 39 957,414 1.26 0.76–2.08 
P for trend   0.35  
Total grains (oz. equivalents/day) 
 <3.37 39 1,107,879 1.00 Ref. 
 3.37–<4.78 42 1,112,903 1.02 0.65–1.60 
 4.78–<6.57 44 1,120,035 1.02 0.65–1.59 
 ≥6.57 53 1,116,745 1.17 0.76–1.80 
P for trend   0.45  
Total fat (g/day) 
 <38.6 37 1,126,983 1.00 Ref. 
 38.6–<55.3 37 1,114,083 0.95 0.59–1.53 
 55.3–<78.5 49 1,114,679 1.21 0.78–1.89 
 ≥78.5 55 1,101,816 1.21 0.78–1.90 
P for trend   0.26  
Total fiber (g/day) 
 <12.7 43 1,103,170 1.00 Ref. 
 12.7–<17.7 37 1,129,612 0.89 0.56–1.40 
 17.7–<24.0 49 1,102,684 1.19 0.78–1.82 
 ≥24.0 49 1,122,097 1.14 0.74–1.75 
P for trend   0.36  
Alcohol intake (drinks/day) 
 Never 41 1,076,913 1.00 Ref. 
 >0–<1 87 2,372,482 1.04 0.70–1.52 
 ≥1–<3 34 680,675 1.19 0.74–1.93 
 ≥3 16 327,493 1.03 0.57–1.86 
P for trend   0.69  
Coffee intake (g/day) 
 0–<376 55 1,571,313 1.00 Ref. 
 376–<957 53 1,420,635 1.20 0.82–1.78 
 ≥957 70 1,494,217 1.00 0.68–1.46 
P for trend   0.64  
Tea intake (g/day) 
 0–<34 66 1,481,435 1.00 Ref. 
 34–<315 53 1,500,004 0.92 0.63–1.33 
 ≥315 59 1,504,726 1.00 0.69–1.44 
P for trend   0.88  
Multivariable modela
No. of casesNo. of person-yearsHR95% CI
Red meat (g/day)b 
 <27.3 33 1,228,647 1.00 Ref. 
 27.3–<51.3 42 1,119,335 1.20 0.74–1.95 
 51.3–<87.6 50 1,108,332 1.36 0.85–2.17 
 ≥87.6 53 1,101,246 1.33 0.83–2.13 
P for trend   0.25  
Total meat (g/day) 
 <67.9 39 1,116,426 1.00 Ref. 
 67.9–<106.9 47 1,112,529 1.12 0.72–1.74 
 106.9–<161.3 48 1,114,098 1.23 0.80–1.90 
 ≥161.3 44 1,114,509 1.11 0.71–1.73 
P for trend   0.65  
White meat (g/day)b 
 <25.8 39 1,101,159 1.00 Ref. 
 25.8–<46.0 50 1,110,974 0.82 0.53–1.26 
 46.0–<77.8 48 1,118,285 1.15 0.76–1.72 
 ≥77.8 41 1,127,144 0.94 0.61–1.46 
P for trend   0.89  
Processed meat (g/day)b 
 <2.8 41 1,127,532 1.00 Ref. 
 2.8–<6.6 38 1,123,322 0.80 0.50–1.26 
 6.6–<15.4 52 1,111,307 1.01 0.65–1.59 
 ≥15.4 47 1,095,399 0.62 0.36–1.07 
P for trend   0.14  
Fish (g/day) 
 <4.2 55 1,110,495 1.00 Ref. 
 4.2–<7.9 51 1,113,299 0.91 0.62–1.35 
 7.9–<14.2 34 1,113,995 0.63 0.41–0.98 
 ≥14.2 38 1,119,773 0.73 0.48–1.11 
P for trend   0.11  
Total fruit (cup equivalents/day) 
 <0.97 37 1,093,153 1.00 Ref. 
 0.97–<1.69 50 1,128,735 1.45 0.93–2.25 
 1.69–<2.65 55 1,110,765 1.68 1.09–2.60 
 ≥2.65 96 1,124,909 1.12 0.69–1.81 
P for trend   0.84  
Total vegetables (cup equivalents/day) 
 <1.14 30 778,204 1.00 Ref. 
 1.14–<1.71 53 1,391,457 1.12 0.70–1.80 
 1.71–<2.48 56 1,330,487 1.28 0.80–2.04 
 ≥2.48 39 957,414 1.26 0.76–2.08 
P for trend   0.35  
Total grains (oz. equivalents/day) 
 <3.37 39 1,107,879 1.00 Ref. 
 3.37–<4.78 42 1,112,903 1.02 0.65–1.60 
 4.78–<6.57 44 1,120,035 1.02 0.65–1.59 
 ≥6.57 53 1,116,745 1.17 0.76–1.80 
P for trend   0.45  
Total fat (g/day) 
 <38.6 37 1,126,983 1.00 Ref. 
 38.6–<55.3 37 1,114,083 0.95 0.59–1.53 
 55.3–<78.5 49 1,114,679 1.21 0.78–1.89 
 ≥78.5 55 1,101,816 1.21 0.78–1.90 
P for trend   0.26  
Total fiber (g/day) 
 <12.7 43 1,103,170 1.00 Ref. 
 12.7–<17.7 37 1,129,612 0.89 0.56–1.40 
 17.7–<24.0 49 1,102,684 1.19 0.78–1.82 
 ≥24.0 49 1,122,097 1.14 0.74–1.75 
P for trend   0.36  
Alcohol intake (drinks/day) 
 Never 41 1,076,913 1.00 Ref. 
 >0–<1 87 2,372,482 1.04 0.70–1.52 
 ≥1–<3 34 680,675 1.19 0.74–1.93 
 ≥3 16 327,493 1.03 0.57–1.86 
P for trend   0.69  
Coffee intake (g/day) 
 0–<376 55 1,571,313 1.00 Ref. 
 376–<957 53 1,420,635 1.20 0.82–1.78 
 ≥957 70 1,494,217 1.00 0.68–1.46 
P for trend   0.64  
Tea intake (g/day) 
 0–<34 66 1,481,435 1.00 Ref. 
 34–<315 53 1,500,004 0.92 0.63–1.33 
 ≥315 59 1,504,726 1.00 0.69–1.44 
P for trend   0.88  

aAdjusted for age, sex, body mass index (<25, 25–<30, ≥30 kg/m2), smoking intensity (never, <21 cigarettes per day, ≥21 cigarettes per day), physical activity (<1, 1–2, >3 times per week), and years of education (<12, 12–<16, ≥16 years), energy intake (kcal/day—continuous).

bRed meat additionally adjusted for intake of white meat and visa versa; processed meat additionally adjusted for intake of unprocessed meat.

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