American Association for Cancer Research

Table 4.

Precision of plasma NMR with replication of NMR measurements

n/subject	Variance of the mean of n replicates	Reliability	Variance inflation relative to n = 2	Variance inflation relative to n = 3
A. All subjects
1	0.080	0.85	1.08	1.11
2	0.074	0.92	1.00	1.03
3	0.072	0.94	0.97	1.00
4	0.071	0.96	0.96	0.99
10	0.069	0.98	0.94	0.96
∞	0.068	1.00	0.92	0.94
B. Outliers removed
1	0.039	0.70	1.18	1.25
2	0.033	0.82	1.00	1.06
3	0.031	0.87	0.94	1.00
4	0.030	0.90	0.91	0.97
10	0.029	0.96	0.86	0.91
∞	0.027	1.00	0.82	0.87

n/subject	Variance of the mean of n replicates	Reliability	Variance inflation relative to n = 2	Variance inflation relative to n = 3
A. All subjects
1	0.080	0.85	1.08	1.11
2	0.074	0.92	1.00	1.03
3	0.072	0.94	0.97	1.00
4	0.071	0.96	0.96	0.99
10	0.069	0.98	0.94	0.96
∞	0.068	1.00	0.92	0.94
B. Outliers removed
1	0.039	0.70	1.18	1.25
2	0.033	0.82	1.00	1.06
3	0.031	0.87	0.94	1.00
4	0.030	0.90	0.91	0.97
10	0.029	0.96	0.86	0.91
∞	0.027	1.00	0.82	0.87

NOTE: n, number of replicate measurements per subject; variance of the mean of n replicates, variance_{between-subjects} + variance_{within-subjects}/n; Reliability, variance_{between-subjects}/total variance; variance inflation of x relative to y, variance of x replicates/variance of y replicates.

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