American Association for Cancer Research

Table 1.

Bland–Altman analysis of agreement between measures

Study	Comparison	Ratio (95% CI)	Range of agreement (ratio ± 2 SD)
A. Comparison between testing sites
Study 4	UCSF vs. UT plasma 3-HC	0.95 (0.89–1.02)	0.74–1.22
	UCSF vs. UT plasma COT	0.89 (0.84–0.94)	0.72–1.10^b
	UCSF vs. UT plasma NMR	1.06 (0.99–1.13)	0.84–1.34^b
B. Comparison between NMR derived from total vs. free 3-HC
Study 4	Urine total vs. free NMR	1.21 (1.18–1.25)	1.02–1.45
C. Comparison between biomarkers in various body fluids of smokers
Study 2	Blood vs. plasma 3-HC	0.97 (0.90–1.04)	0.64–1.48^b
	Blood vs. plasma COT	0.96 (0.91–1.01)	0.69–1.32
	Blood vs. plasma NMR	1.01 (0.95–1.06)	0.72–1.40^b
	Blood vs. saliva 3-HC	0.96 (0.84–1.11)	0.44–2.13
	Blood vs. saliva COT	0.91 (0.83–1.00)	0.53–1.56
	Blood vs. saliva NMR	1.04 (0.95–1.15)	0.61–1.78^b
	Urine vs. blood 3-HC^a	40.7 (30.7–54.1)	7.6–217.8
	Urine vs. blood COT	4.8 (4.1–5.6)	1.94–11.9
	Urine vs. blood NMR^a	8.5 (7.1–10.2)	2.89–24.8
	Saliva vs. plasma 3-HC	1.49 (0.87–1.15)	0.45–2.23
	Saliva vs. plasma COT	1.04 (0.95–1.14)	0.63–1.73
	Saliva vs. plasma NMR	0.96 (0.86–1.07)	0.52–1.77
	Urine vs. plasma 3-HC^a	38.2 (28.9–50.5)	7.5–194.0
	Urine vs. plasma COT	4.6 (4.0–5.3)	2.05–10.3
	Urine vs. plasma NMR^a	8.5 (7.1–10.1)	2.96–24.1
	Urine vs. saliva 3-HC^a	36.4 (27.1–46.6)	6.9–190.8
	Urine vs. saliva COT	4.3 (3.7–5.0)	1.89–9.8
	Urine vs. saliva NMR^a	8.6 (6.9–10.6)	2.60–28.2
D. Comparison between saliva and plasma in smokers and nonsmokers
Study 3	Saliva vs. plasma 3-HC^a	0.87 (0.81–0.95)	0.44–1.75
	Saliva vs. plasma COT	1.01 (0.94–1.08)	0.55–1.85
	Saliva vs. plasma NMR^a	0.88 (0.83–0.94)	0.53–1.47

Study	Comparison	Ratio (95% CI)	Range of agreement (ratio ± 2 SD)
A. Comparison between testing sites
Study 4	UCSF vs. UT plasma 3-HC	0.95 (0.89–1.02)	0.74–1.22
	UCSF vs. UT plasma COT	0.89 (0.84–0.94)	0.72–1.10^b
	UCSF vs. UT plasma NMR	1.06 (0.99–1.13)	0.84–1.34^b
B. Comparison between NMR derived from total vs. free 3-HC
Study 4	Urine total vs. free NMR	1.21 (1.18–1.25)	1.02–1.45
C. Comparison between biomarkers in various body fluids of smokers
Study 2	Blood vs. plasma 3-HC	0.97 (0.90–1.04)	0.64–1.48^b
	Blood vs. plasma COT	0.96 (0.91–1.01)	0.69–1.32
	Blood vs. plasma NMR	1.01 (0.95–1.06)	0.72–1.40^b
	Blood vs. saliva 3-HC	0.96 (0.84–1.11)	0.44–2.13
	Blood vs. saliva COT	0.91 (0.83–1.00)	0.53–1.56
	Blood vs. saliva NMR	1.04 (0.95–1.15)	0.61–1.78^b
	Urine vs. blood 3-HC^a	40.7 (30.7–54.1)	7.6–217.8
	Urine vs. blood COT	4.8 (4.1–5.6)	1.94–11.9
	Urine vs. blood NMR^a	8.5 (7.1–10.2)	2.89–24.8
	Saliva vs. plasma 3-HC	1.49 (0.87–1.15)	0.45–2.23
	Saliva vs. plasma COT	1.04 (0.95–1.14)	0.63–1.73
	Saliva vs. plasma NMR	0.96 (0.86–1.07)	0.52–1.77
	Urine vs. plasma 3-HC^a	38.2 (28.9–50.5)	7.5–194.0
	Urine vs. plasma COT	4.6 (4.0–5.3)	2.05–10.3
	Urine vs. plasma NMR^a	8.5 (7.1–10.1)	2.96–24.1
	Urine vs. saliva 3-HC^a	36.4 (27.1–46.6)	6.9–190.8
	Urine vs. saliva COT	4.3 (3.7–5.0)	1.89–9.8
	Urine vs. saliva NMR^a	8.6 (6.9–10.6)	2.60–28.2
D. Comparison between saliva and plasma in smokers and nonsmokers
Study 3	Saliva vs. plasma 3-HC^a	0.87 (0.81–0.95)	0.44–1.75
	Saliva vs. plasma COT	1.01 (0.94–1.08)	0.55–1.85
	Saliva vs. plasma NMR^a	0.88 (0.83–0.94)	0.53–1.47

NOTE: Ratio, back-transformation of mean difference between measures on log-scale; 95% CI of ratio, back-transformation of 95% CI of the mean difference between measures on log-scale; range of agreement, back-transformation of the mean difference between measures on a log-scale ± 2 SDs from the mean difference.

^aUrine total 3-HC was used in analysis.

^bMeasures are consistently similar, that is, measures were not observed outside the limit of agreement of mean bias ± 2 SDs.

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