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Table 1.

Bland–Altman analysis of agreement between measures

StudyComparisonRatio (95% CI)Range of agreement (ratio ± 2 SD)
A. Comparison between testing sites 
Study 4 UCSF vs. UT plasma 3-HC 0.95 (0.89–1.02) 0.74–1.22 
 UCSF vs. UT plasma COT 0.89 (0.84–0.94) 0.72–1.10b 
 UCSF vs. UT plasma NMR 1.06 (0.99–1.13) 0.84–1.34b 
B. Comparison between NMR derived from total vs. free 3-HC 
Study 4 Urine total vs. free NMR 1.21 (1.18–1.25) 1.02–1.45 
C. Comparison between biomarkers in various body fluids of smokers 
Study 2 Blood vs. plasma 3-HC 0.97 (0.90–1.04) 0.64–1.48b 
 Blood vs. plasma COT 0.96 (0.91–1.01) 0.69–1.32 
 Blood vs. plasma NMR 1.01 (0.95–1.06) 0.72–1.40b 
 Blood vs. saliva 3-HC 0.96 (0.84–1.11) 0.44–2.13 
 Blood vs. saliva COT 0.91 (0.83–1.00) 0.53–1.56 
 Blood vs. saliva NMR 1.04 (0.95–1.15) 0.61–1.78b 
 Urine vs. blood 3-HCa 40.7 (30.7–54.1) 7.6–217.8 
 Urine vs. blood COT 4.8 (4.1–5.6) 1.94–11.9 
 Urine vs. blood NMRa 8.5 (7.1–10.2) 2.89–24.8 
 Saliva vs. plasma 3-HC 1.49 (0.87–1.15) 0.45–2.23 
 Saliva vs. plasma COT 1.04 (0.95–1.14) 0.63–1.73 
 Saliva vs. plasma NMR 0.96 (0.86–1.07) 0.52–1.77 
 Urine vs. plasma 3-HCa 38.2 (28.9–50.5) 7.5–194.0 
 Urine vs. plasma COT 4.6 (4.0–5.3) 2.05–10.3 
 Urine vs. plasma NMRa 8.5 (7.1–10.1) 2.96–24.1 
 Urine vs. saliva 3-HCa 36.4 (27.1–46.6) 6.9–190.8 
 Urine vs. saliva COT 4.3 (3.7–5.0) 1.89–9.8 
 Urine vs. saliva NMRa 8.6 (6.9–10.6) 2.60–28.2 
D. Comparison between saliva and plasma in smokers and nonsmokers 
Study 3 Saliva vs. plasma 3-HCa 0.87 (0.81–0.95) 0.44–1.75 
 Saliva vs. plasma COT 1.01 (0.94–1.08) 0.55–1.85 
 Saliva vs. plasma NMRa 0.88 (0.83–0.94) 0.53–1.47 
StudyComparisonRatio (95% CI)Range of agreement (ratio ± 2 SD)
A. Comparison between testing sites 
Study 4 UCSF vs. UT plasma 3-HC 0.95 (0.89–1.02) 0.74–1.22 
 UCSF vs. UT plasma COT 0.89 (0.84–0.94) 0.72–1.10b 
 UCSF vs. UT plasma NMR 1.06 (0.99–1.13) 0.84–1.34b 
B. Comparison between NMR derived from total vs. free 3-HC 
Study 4 Urine total vs. free NMR 1.21 (1.18–1.25) 1.02–1.45 
C. Comparison between biomarkers in various body fluids of smokers 
Study 2 Blood vs. plasma 3-HC 0.97 (0.90–1.04) 0.64–1.48b 
 Blood vs. plasma COT 0.96 (0.91–1.01) 0.69–1.32 
 Blood vs. plasma NMR 1.01 (0.95–1.06) 0.72–1.40b 
 Blood vs. saliva 3-HC 0.96 (0.84–1.11) 0.44–2.13 
 Blood vs. saliva COT 0.91 (0.83–1.00) 0.53–1.56 
 Blood vs. saliva NMR 1.04 (0.95–1.15) 0.61–1.78b 
 Urine vs. blood 3-HCa 40.7 (30.7–54.1) 7.6–217.8 
 Urine vs. blood COT 4.8 (4.1–5.6) 1.94–11.9 
 Urine vs. blood NMRa 8.5 (7.1–10.2) 2.89–24.8 
 Saliva vs. plasma 3-HC 1.49 (0.87–1.15) 0.45–2.23 
 Saliva vs. plasma COT 1.04 (0.95–1.14) 0.63–1.73 
 Saliva vs. plasma NMR 0.96 (0.86–1.07) 0.52–1.77 
 Urine vs. plasma 3-HCa 38.2 (28.9–50.5) 7.5–194.0 
 Urine vs. plasma COT 4.6 (4.0–5.3) 2.05–10.3 
 Urine vs. plasma NMRa 8.5 (7.1–10.1) 2.96–24.1 
 Urine vs. saliva 3-HCa 36.4 (27.1–46.6) 6.9–190.8 
 Urine vs. saliva COT 4.3 (3.7–5.0) 1.89–9.8 
 Urine vs. saliva NMRa 8.6 (6.9–10.6) 2.60–28.2 
D. Comparison between saliva and plasma in smokers and nonsmokers 
Study 3 Saliva vs. plasma 3-HCa 0.87 (0.81–0.95) 0.44–1.75 
 Saliva vs. plasma COT 1.01 (0.94–1.08) 0.55–1.85 
 Saliva vs. plasma NMRa 0.88 (0.83–0.94) 0.53–1.47 

NOTE: Ratio, back-transformation of mean difference between measures on log-scale; 95% CI of ratio, back-transformation of 95% CI of the mean difference between measures on log-scale; range of agreement, back-transformation of the mean difference between measures on a log-scale ± 2 SDs from the mean difference.

aUrine total 3-HC was used in analysis.

bMeasures are consistently similar, that is, measures were not observed outside the limit of agreement of mean bias ± 2 SDs.

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