Skip to Main Content
Table 4.

Associations of fish oil supplement use with subsets of breast cancer defined by histology and stage, among female VITAL participants (n = 35,016)

Fish oil*
NonuserCurrent user
Cases/noncasesHR (95% CI)Cases/noncasesHR (95% CI)
Histology 
    Ductal carcinoma (n = 632) 579/30,331 1.00 (reference) 29/2,668 0.56 (0.38-0.83) 
    Lobular carcinoma (n = 172) 153/30,331 1.00 (reference) 13/2,668 1.08 (0.59-1.96) 
    P difference    <0.05 
SEER summary stage 
    Local (n = 626) 578/30,331 1.00 (reference) 29/2,668 0.57 (0.38-0.84) 
    Regional/distant (n = 251) 221/30,331 1.00 (reference) 18/2,668 0.97 (0.59-1.61) 
    P difference    0.06 
Hormone receptor status 
    ER+ (n = 737) 669/30,331 1.00 (reference) 29/2,668 0.64 (0.46-0.91) 
    ER (n = 125) 118/30,331 1.00 (reference) 1/2,668 0.61 (0.27-1.40) 
    P difference    0.49 
    PR+ (n = 640) 584/30,331 1.00 (reference) 22/2,668 0.63 (0.43-0.92) 
    PR (n = 221) 202/30,331 1.00 (reference) 8/2,668 0.67 (0.36-1.23) 
    P difference    0.96 
Fish oil*
NonuserCurrent user
Cases/noncasesHR (95% CI)Cases/noncasesHR (95% CI)
Histology 
    Ductal carcinoma (n = 632) 579/30,331 1.00 (reference) 29/2,668 0.56 (0.38-0.83) 
    Lobular carcinoma (n = 172) 153/30,331 1.00 (reference) 13/2,668 1.08 (0.59-1.96) 
    P difference    <0.05 
SEER summary stage 
    Local (n = 626) 578/30,331 1.00 (reference) 29/2,668 0.57 (0.38-0.84) 
    Regional/distant (n = 251) 221/30,331 1.00 (reference) 18/2,668 0.97 (0.59-1.61) 
    P difference    0.06 
Hormone receptor status 
    ER+ (n = 737) 669/30,331 1.00 (reference) 29/2,668 0.64 (0.46-0.91) 
    ER (n = 125) 118/30,331 1.00 (reference) 1/2,668 0.61 (0.27-1.40) 
    P difference    0.49 
    PR+ (n = 640) 584/30,331 1.00 (reference) 22/2,668 0.63 (0.43-0.92) 
    PR (n = 221) 202/30,331 1.00 (reference) 8/2,668 0.67 (0.36-1.23) 
    P difference    0.96 

*Former users dropped from analysis.

Adjusted for age, race, education, BMI, height, fruit consumption, vegetable consumption, alcohol consumption, physical activity, age at menarche, age at menopause, age at first birth, history of hysterectomy, years of combined hormone therapy, family history of breast cancer, history of benign breast biopsy, mammography, low-dose aspirin use, regular aspirin use, ibuprofen use, naproxen use, use of multivitamins, memory loss, and CAD.

Close Modal

or Create an Account

Close Modal
Close Modal