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Table 2.

A. Thyroid Cancer Incidence in Women in SEER's 9-Registry Database (1976-2005); percentage change over time
Calendar-period
1976-85
1986-95
1996-2005
%CH 1976-85 or 1988*-95 to 1996-2005
VariableNRateSENRateSENRateSE%CHLLUL
Total (N = 34,850) 6,953 6.6 0.08 9,508 7.8 0.08 16,784 12.1 0.09 83.9% 70.7% 76.6% 
Histopathology             
    Papillary 5,088 4.8 0.07 7,611 6.3 0.07 14,368 10.4 0.09 117.5% 108.4% 127.4% 
    Follicular 1,196 1.2 0.03 1,287 1.1 0.03 1,659 1.2 0.03 2.9% 2.8% 3.1% 
    Medullary 213 0.2 0.02 219 0.2 0.01 285 0.2 0.01 -1.0% -85.9% -1.1% 
    Anaplastic 154 0.1 0.01 131 0.1 0.01 159 0.1 0.01 -26.5% -23.5% -29.9% 
    Other/Unknown 388 0.4 0.02 475 0.4 0.02 806 0.6 0.02 47.7% 42.9% 53.0% 
Papillary (N = 28,180)             
Age in years             
    0-9 ∼ ∼ ∼ ∼ ∼ ∼ ∼ ∼ ∼ 
    10-19 216 1.2 0.08 238 1.5 0.10 312 1.7 0.10 46.5% 39.0% 55.5% 
    20-29 1,169 5.9 0.17 1,261 6.5 0.19 1,708 9.3 0.23 57.5% 51.5% 64.2% 
    30-39 1,219 7.5 0.22 2,041 9.8 0.22 3,269 15.6 0.27 107.1% 89.3% 128.6% 
    40-49 882 7.7 0.26 1,634 10.2 0.25 3,673 17.4 0.29 125.1% 98.3% 159.2% 
    50-59 738 6.7 0.25 1,070 9.9 0.31 2,701 17.4 0.34 158.0% 115.4% 216.4% 
    60-69 479 5.2 0.24 769 7.8 0.28 1,478 15.1 0.39 188.4% 124.7% 284.8% 
    70-79 274 4.6 0.28 438 5.9 0.28 897 11.2 0.37 144.1% 96.7% 214.8% 
    80+ 102 3.1 0.31 156 3.6 0.29 321 5.8 0.32 83.9% 59.0% 119.2% 
Race             
    White 4,300 4.8 0.08 6,287 6.4 0.08 11,763 11.1 0.10 130.8% 118.6% 144.3% 
    Black 228 2.4 0.17 362 3.0 0.17 820 5.3 0.19 124.2% 91.3% 168.8% 
    Other 530 8.2 0.38 918 8.9 0.30 1,632 10.6 0.27 29.3% 26.5% 32.3% 
    Unknown 30 ∼ ∼ 44 ∼ ∼ 153 ∼ ∼ ∼ ∼ ∼ 
SEER Stage             
    Localized 3,210 3.1 0.06 4,479 3.7 0.06 9,532 6.9 0.07 124.7% 114.0% 136.5% 
    Regional 1,589 1.5 0.04 2,612 2.1 0.04 4,258 3.1 0.05 111.9% 101.9% 122.9% 
    Distant 177 0.2 0.01 261 0.2 0.01 359 0.3 0.01 64.3% 53.8% 76.9% 
    Unknown 112 ∼ ∼ 259 ∼ ∼ 219 ∼ ∼ ∼ ∼ ∼ 
Tumor Size (1988+)             
    0-1 cm ∼ ∼ ∼ 1,213 1.2 0.04 4,184 3.0 0.05 144.9% 128.8% 163.2% 
    >1 and ≤2 cm ∼ ∼ ∼ 1,845 1.9 0.04 3,951 2.9 0.05 53.3% 50.2% 56.5% 
    >2 and ≤4 cm ∼ ∼ ∼ 1,446 1.4 0.04 3,095 2.2 0.04 54.7% 51.3% 58.3% 
    4+ cm ∼ ∼ ∼ 281 0.2 0.01 783 0.6 0.02 150.7% 124.0% 183.1% 
    Unknown 5,088 ∼ ∼ 2,826 ∼ ∼ 2,355 ∼ ∼ ∼ ∼ ∼ 
             
B. Thyroid Cancer Incidence in Men in SEER's 9-Registry Database (1976-2005); percentage change over time
 
            
Calendar-period
 
1976-85
 
  1986-95
 
  1996-2005
 
  %CH 1976-85 or 1988*-95 to 1996-2005
 
  
Variable N Rate SE N Rate SE N Rate SE %CH LL UL 
Total (N = 12,109) 2,591 2.9 0.06 3,378 3.2 0.06 5,491 4.3 0.06 52.0% 49.2% 54.8% 
Histopathology             
    Papillary 1,797 1.9 0.05 2,447 2.3 0.05 4,369 3.4 0.05 77.8% 72.3% 83.8% 
    Follicular 455 0.5 0.03 557 0.5 0.02 647 0.5 0.02 2.1% 2.0% 2.3% 
    Medullary 131 0.1 0.01 150 0.1 0.01 195 0.2 0.01 6.8% 5.9% 7.9% 
    Anaplastic 72 0.1 0.01 90 0.1 0.01 104 0.1 0.01 -3.1% -2.6% -3.7% 
    Other/Unknown 167 0.2 0.02 245 0.3 0.02 371 0.3 0.02 48.1% 41.0% 56.5% 
Papillary (N = 9,045)             
Age in years             
    0-9 ∼ ∼ ∼ ∼ ∼ ∼ ∼ ∼ ∼ 
    10-19 53 0.3 0.04 36 0.2 0.04 58 0.3 0.04 7.9% 6.0% 10.4% 
    20-29 241 1.2 0.08 260 1.3 0.08 343 1.8 0.10 47.3% 39.9% 56.1% 
    30-39 414 2.6 0.13 509 2.5 0.11 738 3.5 0.13 31.8% 28.5% 35.4% 
    40-49 305 2.8 0.16 487 3.1 0.14 992 4.8 0.15 73.2% 61.5% 87.1% 
    50-59 336 3.2 0.18 420 4.1 0.20 1,001 6.7 0.21 110.9% 86.4% 142.5% 
    60-69 269 3.5 0.21 422 5.0 0.24 689 7.9 0.30 128.2% 91.9% 178.8% 
    70-79 123 3.0 0.27 244 4.5 0.29 394 6.5 0.33 116.4% 76.6% 176.8% 
    80+ 50 3.1 0.45 67 3.2 0.39 149 4.8 0.40 53.9% 37.4% 77.5% 
Race             
    White 1,487 1.8 0.05 2,113 2.3 0.05 3,754 3.7 0.06 98.8% 89.7% 108.7% 
    Black 63 0.9 0.12 93 1.0 0.11 184 1.6 0.13 80.6% 57.3% 113.5% 
    Other 236 4.4 0.31 227 2.8 0.20 396 3.1 0.16 -30.3% -27.1% -33.9% 
    Unknown 11 ∼ ∼ 14 ∼ ∼ 35 ∼ ∼ ∼ ∼ ∼ 
SEER Stage             
    Localized 960 1.0 0.04 1,174 1.1 0.03 2,337 1.8 0.04 75.4% 69.1% 82.3% 
    Regional 665 0.7 0.03 1,051 1.0 0.03 1,680 1.3 0.03 87.2% 78.4% 97.0% 
    Distant 126 0.1 0.01 140 0.1 0.01 267 0.2 0.01 60.9% 49.7% 74.6% 
    Unknown 46 ∼ ∼ 82 ∼ ∼ 85 ∼ ∼ ∼ ∼ ∼ 
Tumor Size (1988+)             
    0-1 cm ∼ ∼ ∼ 318 0.4 0.02 1,004 0.8 0.03 114.4% 98.1% 133.5% 
    >1 and ≤2 cm ∼ ∼ ∼ 436 0.5 0.02 1,000 0.8 0.02 58.7% 52.8% 65.2% 
    >2 and ≤4 cm ∼ ∼ ∼ 479 0.5 0.02 1,009 0.8 0.03 49.0% 44.4% 54.2% 
    4+ cm ∼ ∼ ∼ 202 0.2 0.01 502 0.4 0.02 107.9% 88.5% 131.5% 
    Unknown 1,797 ∼ ∼ 1,012 ∼ ∼ 854 ∼ ∼ ∼ ∼ ∼ 
A. Thyroid Cancer Incidence in Women in SEER's 9-Registry Database (1976-2005); percentage change over time
Calendar-period
1976-85
1986-95
1996-2005
%CH 1976-85 or 1988*-95 to 1996-2005
VariableNRateSENRateSENRateSE%CHLLUL
Total (N = 34,850) 6,953 6.6 0.08 9,508 7.8 0.08 16,784 12.1 0.09 83.9% 70.7% 76.6% 
Histopathology             
    Papillary 5,088 4.8 0.07 7,611 6.3 0.07 14,368 10.4 0.09 117.5% 108.4% 127.4% 
    Follicular 1,196 1.2 0.03 1,287 1.1 0.03 1,659 1.2 0.03 2.9% 2.8% 3.1% 
    Medullary 213 0.2 0.02 219 0.2 0.01 285 0.2 0.01 -1.0% -85.9% -1.1% 
    Anaplastic 154 0.1 0.01 131 0.1 0.01 159 0.1 0.01 -26.5% -23.5% -29.9% 
    Other/Unknown 388 0.4 0.02 475 0.4 0.02 806 0.6 0.02 47.7% 42.9% 53.0% 
Papillary (N = 28,180)             
Age in years             
    0-9 ∼ ∼ ∼ ∼ ∼ ∼ ∼ ∼ ∼ 
    10-19 216 1.2 0.08 238 1.5 0.10 312 1.7 0.10 46.5% 39.0% 55.5% 
    20-29 1,169 5.9 0.17 1,261 6.5 0.19 1,708 9.3 0.23 57.5% 51.5% 64.2% 
    30-39 1,219 7.5 0.22 2,041 9.8 0.22 3,269 15.6 0.27 107.1% 89.3% 128.6% 
    40-49 882 7.7 0.26 1,634 10.2 0.25 3,673 17.4 0.29 125.1% 98.3% 159.2% 
    50-59 738 6.7 0.25 1,070 9.9 0.31 2,701 17.4 0.34 158.0% 115.4% 216.4% 
    60-69 479 5.2 0.24 769 7.8 0.28 1,478 15.1 0.39 188.4% 124.7% 284.8% 
    70-79 274 4.6 0.28 438 5.9 0.28 897 11.2 0.37 144.1% 96.7% 214.8% 
    80+ 102 3.1 0.31 156 3.6 0.29 321 5.8 0.32 83.9% 59.0% 119.2% 
Race             
    White 4,300 4.8 0.08 6,287 6.4 0.08 11,763 11.1 0.10 130.8% 118.6% 144.3% 
    Black 228 2.4 0.17 362 3.0 0.17 820 5.3 0.19 124.2% 91.3% 168.8% 
    Other 530 8.2 0.38 918 8.9 0.30 1,632 10.6 0.27 29.3% 26.5% 32.3% 
    Unknown 30 ∼ ∼ 44 ∼ ∼ 153 ∼ ∼ ∼ ∼ ∼ 
SEER Stage             
    Localized 3,210 3.1 0.06 4,479 3.7 0.06 9,532 6.9 0.07 124.7% 114.0% 136.5% 
    Regional 1,589 1.5 0.04 2,612 2.1 0.04 4,258 3.1 0.05 111.9% 101.9% 122.9% 
    Distant 177 0.2 0.01 261 0.2 0.01 359 0.3 0.01 64.3% 53.8% 76.9% 
    Unknown 112 ∼ ∼ 259 ∼ ∼ 219 ∼ ∼ ∼ ∼ ∼ 
Tumor Size (1988+)             
    0-1 cm ∼ ∼ ∼ 1,213 1.2 0.04 4,184 3.0 0.05 144.9% 128.8% 163.2% 
    >1 and ≤2 cm ∼ ∼ ∼ 1,845 1.9 0.04 3,951 2.9 0.05 53.3% 50.2% 56.5% 
    >2 and ≤4 cm ∼ ∼ ∼ 1,446 1.4 0.04 3,095 2.2 0.04 54.7% 51.3% 58.3% 
    4+ cm ∼ ∼ ∼ 281 0.2 0.01 783 0.6 0.02 150.7% 124.0% 183.1% 
    Unknown 5,088 ∼ ∼ 2,826 ∼ ∼ 2,355 ∼ ∼ ∼ ∼ ∼ 
             
B. Thyroid Cancer Incidence in Men in SEER's 9-Registry Database (1976-2005); percentage change over time
 
            
Calendar-period
 
1976-85
 
  1986-95
 
  1996-2005
 
  %CH 1976-85 or 1988*-95 to 1996-2005
 
  
Variable N Rate SE N Rate SE N Rate SE %CH LL UL 
Total (N = 12,109) 2,591 2.9 0.06 3,378 3.2 0.06 5,491 4.3 0.06 52.0% 49.2% 54.8% 
Histopathology             
    Papillary 1,797 1.9 0.05 2,447 2.3 0.05 4,369 3.4 0.05 77.8% 72.3% 83.8% 
    Follicular 455 0.5 0.03 557 0.5 0.02 647 0.5 0.02 2.1% 2.0% 2.3% 
    Medullary 131 0.1 0.01 150 0.1 0.01 195 0.2 0.01 6.8% 5.9% 7.9% 
    Anaplastic 72 0.1 0.01 90 0.1 0.01 104 0.1 0.01 -3.1% -2.6% -3.7% 
    Other/Unknown 167 0.2 0.02 245 0.3 0.02 371 0.3 0.02 48.1% 41.0% 56.5% 
Papillary (N = 9,045)             
Age in years             
    0-9 ∼ ∼ ∼ ∼ ∼ ∼ ∼ ∼ ∼ 
    10-19 53 0.3 0.04 36 0.2 0.04 58 0.3 0.04 7.9% 6.0% 10.4% 
    20-29 241 1.2 0.08 260 1.3 0.08 343 1.8 0.10 47.3% 39.9% 56.1% 
    30-39 414 2.6 0.13 509 2.5 0.11 738 3.5 0.13 31.8% 28.5% 35.4% 
    40-49 305 2.8 0.16 487 3.1 0.14 992 4.8 0.15 73.2% 61.5% 87.1% 
    50-59 336 3.2 0.18 420 4.1 0.20 1,001 6.7 0.21 110.9% 86.4% 142.5% 
    60-69 269 3.5 0.21 422 5.0 0.24 689 7.9 0.30 128.2% 91.9% 178.8% 
    70-79 123 3.0 0.27 244 4.5 0.29 394 6.5 0.33 116.4% 76.6% 176.8% 
    80+ 50 3.1 0.45 67 3.2 0.39 149 4.8 0.40 53.9% 37.4% 77.5% 
Race             
    White 1,487 1.8 0.05 2,113 2.3 0.05 3,754 3.7 0.06 98.8% 89.7% 108.7% 
    Black 63 0.9 0.12 93 1.0 0.11 184 1.6 0.13 80.6% 57.3% 113.5% 
    Other 236 4.4 0.31 227 2.8 0.20 396 3.1 0.16 -30.3% -27.1% -33.9% 
    Unknown 11 ∼ ∼ 14 ∼ ∼ 35 ∼ ∼ ∼ ∼ ∼ 
SEER Stage             
    Localized 960 1.0 0.04 1,174 1.1 0.03 2,337 1.8 0.04 75.4% 69.1% 82.3% 
    Regional 665 0.7 0.03 1,051 1.0 0.03 1,680 1.3 0.03 87.2% 78.4% 97.0% 
    Distant 126 0.1 0.01 140 0.1 0.01 267 0.2 0.01 60.9% 49.7% 74.6% 
    Unknown 46 ∼ ∼ 82 ∼ ∼ 85 ∼ ∼ ∼ ∼ ∼ 
Tumor Size (1988+)             
    0-1 cm ∼ ∼ ∼ 318 0.4 0.02 1,004 0.8 0.03 114.4% 98.1% 133.5% 
    >1 and ≤2 cm ∼ ∼ ∼ 436 0.5 0.02 1,000 0.8 0.02 58.7% 52.8% 65.2% 
    >2 and ≤4 cm ∼ ∼ ∼ 479 0.5 0.02 1,009 0.8 0.03 49.0% 44.4% 54.2% 
    4+ cm ∼ ∼ ∼ 202 0.2 0.01 502 0.4 0.02 107.9% 88.5% 131.5% 
    Unknown 1,797 ∼ ∼ 1,012 ∼ ∼ 854 ∼ ∼ ∼ ∼ ∼ 

NOTE: [A] Key: N, number of cases; Rate per 100,000 woman-years (age-adjusted to the 2000 US standard population); SE, standard error; %CH, percentage change in rates; LB, UB, 95% lower and upper limits, respectively; ∼, not calculated, not applicable, or <10 cases. [B] Key: N, number of cases; Rate per 100,000 man-years (age-adjusted to the 2000 US standard population); SE, standard error; %CH, percentage change in rates; LB, UB, 95% lower and upper limits, respectively; ∼, not calculated, not applicable, or <10 cases.

*

For tumor size, the percent change reflects the change from 1988-95 to 1996-2005.

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