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Table 4.

RR (95% CI) of BCC and SCC by group of serum selenium concentration at baseline in 485 participants of the Nambour Skin Cancer Study, 1996-2004

Selenium concentration
Ptrend
Group 1Group 2Group 3
Median (μmol/L*; min-max) 0.9 (0.4-1.0) 1.1 (1.1-1.2) 1.4 (1.3-2.8)  
BCC: person-based     
    No. persons affected/total participants 33/194 28/163 16/128  
    Basic RR (95% CI) 1.00 1.02 (0.61-1.69) 0.67 (0.37-1.22) 0.19 
    Multivariate RR (95% CI) 1.00 0.97 (0.58-1.61) 0.58 (0.32-1.07) 0.08 
BCC: tumor-based     
    No. tumors/total participants 20/163 22/159 17/163  
    Basic RR (95% CI) 1.00 1.09 (0.56-2.10) 0.57 (0.28-1.17) 0.14 
    Multivariate RR (95% CI) 1.00 1.02 (0.56-1.87) 0.43 (0.21-0.86) 0.02 
SCC: person-based     
    No. persons affected/total participants 27/194 21/163 11/128  
    Basic RR (95% CI) 1.00 0.92 (0.52-1.63) 0.54 (0.27-1.08) 0.08 
    Multivariate RR (95% CI) 1.00 0.89 (0.49-1.60) 0.49 (0.24-0.99) 0.05 
SCC: tumor-based     
    No. tumors/total participants 17/162 21/158 21/165  
    Basic RR (95% CI) 1.00 0.97 (0.48-1.95) 0.44 (0.19-1.00) 0.06 
    Multivariate RR (95% CI) 1.00 0.86 (0.44-1.67) 0.36 (0.15-0.82) 0.02 
Selenium concentration
Ptrend
Group 1Group 2Group 3
Median (μmol/L*; min-max) 0.9 (0.4-1.0) 1.1 (1.1-1.2) 1.4 (1.3-2.8)  
BCC: person-based     
    No. persons affected/total participants 33/194 28/163 16/128  
    Basic RR (95% CI) 1.00 1.02 (0.61-1.69) 0.67 (0.37-1.22) 0.19 
    Multivariate RR (95% CI) 1.00 0.97 (0.58-1.61) 0.58 (0.32-1.07) 0.08 
BCC: tumor-based     
    No. tumors/total participants 20/163 22/159 17/163  
    Basic RR (95% CI) 1.00 1.09 (0.56-2.10) 0.57 (0.28-1.17) 0.14 
    Multivariate RR (95% CI) 1.00 1.02 (0.56-1.87) 0.43 (0.21-0.86) 0.02 
SCC: person-based     
    No. persons affected/total participants 27/194 21/163 11/128  
    Basic RR (95% CI) 1.00 0.92 (0.52-1.63) 0.54 (0.27-1.08) 0.08 
    Multivariate RR (95% CI) 1.00 0.89 (0.49-1.60) 0.49 (0.24-0.99) 0.05 
SCC: tumor-based     
    No. tumors/total participants 17/162 21/158 21/165  
    Basic RR (95% CI) 1.00 0.97 (0.48-1.95) 0.44 (0.19-1.00) 0.06 
    Multivariate RR (95% CI) 1.00 0.86 (0.44-1.67) 0.36 (0.15-0.82) 0.02 
*

1 μmol/L ≈ 79 μg/L.

Adjusted for age and sex. RRs from Poisson regression (person-based) or negative binomial regression (tumor-based).

Adjusted for age, sex, pack-years of smoking, alcohol intake (continuous), time spent outdoors on weekdays, and history of skin cancer before 1996.

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